Persantin | Dipyridamole

Persantin 75 mg

1coated tablet contains: Dipyridamole 75mg

Company Name
CID/Boehringer

Therapeutic Group
CORON THER EX CA/ANT/NIT

Pharmaceutical form
Tablet

Package
Coated tablets of 75 mg

Indications
As an adjunct to oral anticoagulation for prophylaxis of thromboembolism associated with mechanical prosthetic heart valves.

Warning & Precautions
- Among other properties, dipyridamole acts as a vasodilator. It should be used with caution in patients with severe coronary artery disease, including unstable angina and recent myocardial infarction,left ventricular outflow obstruction or haemodynamic instability (e.g.decompensated heart failure).patients treated with regular oral doses of PERSANTIN should not receive additional intravenous PERSANTIN. - In patients with myasthenia gravis, readjustment of therapy may be necessary after changes in dipyridamole dosage (see interaction). - A small number of cases have been reported in which unconjugated dipyridamole was shown to be incorporated into gallstones to a variable extent (up to 70%by dry weight of stone). These patients were elderly, had evidence of ascending cholangitis and had been treated with oral dipyridamole for a number of years. There is no evidence that dipyridamole was the initiating factor in causing gallstones to form in these patients. It is possible that bacterial deglucuronidation of conjugated dipyridamole in bile may be the mechanism responsible for the presence of dipyridamole in gallstones. - Pregnancy and lactation: There is inadequate evidence of safety in human pregnancy, but PERSANTIN has been used for many years without apparent ill-consequence. Preclinical studies have shown no hazard. Nevertheless, medicines should not be used in pregnancy, especially the first trimester, unless the expected benefit is thought to outweigh the possible risk to the foetus. PERSANTIN should only be used during lactation if considered essential by the physician.

Product Type
human

Dosage
A dosage range of 300-450 mg/day in divided doses is recommended. The maximum daily dose is 600 mg. There is only limited information on the use of PERSANTIN in children.

Adverse Reactions
Adverse effects at therapeutic doses are usually mild and transient: - Vomiting, diarrhoea and symptoms such as dizziness, nausea, headache and myalgia have been observed. Such effects usually disappear on long-term use of PERSANTIN. - As a result of its vasodilator properties, PERSANTIN may cause hypotension, hot flushes and tachycardia. Worsening of symptoms of coronary heart disease has been observed. - Hypersensitivity reactions such as rash, urticaria, severe bronchospasm and angio-oedema have been reported. - In very rare cases, increased bleeding during or after surgery has been observed. - Isolated cases of thrombocytopenia have been reported in conjunction with treatment with PERSANTIN. - Dipyridamole has been shown to be incorporated into gallstones (see Special Warnings and Precautions).

Contra Indications
Hypersensitivity to any of components of the product.

Drug Interactions
- Dipyridamole increase plasma levels and cardiovascular effects of adenosine. Adjustment of adenosine dosage should be considered. - When dipyridamole is used in combination with anticoagulants and acetylsalicylic acid, the statements on intolerance and risks for these preparations must be observed. Addition of dipyridamole to acetylsalicylic acid does not increase the incidence of bleeding events. When dipyridamole was administered concomitantly with warfarin, bleeding was no greater in frequency or severity than that observed when warfarin was administered alone. - Dipyridamole may increase the hypotensive effect of drugs which reduce blood pressure and may counteract the anticholinesterase effect of cholinesterase inhibitors thereby potentially aggravating myasthenia gravis.

Search Post

Label :

Mucosolvan Ampoule | Ambroxol

Mucosolvan | Ambroxol 

Mucosolvan 15 mg/Ampoule

Each ampoule (2 ml) contains 15 mg Ambroxol Hcl

Company Name

CID/Boehringer - Egypt

Therapeutic Group

EXPECTORANTS

Pharmaceutical form

Ampoule

Package

Box of 10 ampoules of 2 ml.

Mucosolvan /Ambroxol Indications

- Secretolytic therapy in acute and chronic bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport, such as acute exacerbation of chronic bronchitis, bronchiectasis, asthmoid bronchitis and bronchial asthma. - In pre- and post operative treatment. - The ampoules are especially suitable for prevention of the pulmonary complications in intensive medicine.

Mucosolvan /Ambroxol Warning & Precautions

- Preclinical studies as well as extensive clinical experience after the 28th week have shown no evidence of ill-effects during pregnancy. Nonetheless, the usual precautions regarding the use of drugs during pregnancy, especially during the first trimester, should be observed. - The drug enters breast milk, but is not likely to affect the infant when therapeutic doses are used. - Mucosolvan solution contains the preservative benzalkonium chloride. It has been reported that this preservative may cause bronchoconstriction on some patients with hyper-reactive airways.


Product Type
human

Mucosolvan /Ambroxol Dosage

- Mucosolvan ampoules: Adults: In general, good results have been obtained with the administration of 1 ampoule 2 or 3 times daily. In severe cases the single dose may be increased to 2 ampoules. Administration should be IV or IM, although SC application is also well tolerated. Children over 5 years: 1 ampoule 2-3 times daily. Children 2 - 5 years : ½ ampoule 3 times daily. Children under 2 years: ½ ampoule twice daily. Administration for children should be IV although IM application is also well tolerated. N.B. - If the IV administration is too rapid, headache, pain in the legs and exhaustion may occur. - The solution can also be administered as a drip infusion together with glucose, laevulose, saline or Ringer's solution . - Mucosolvan (pH 5.0) should not be mixed with other solution with a pH greater than 6.3 as precipitation of the free Mucosolvan base can result due to the pH increase. - The combination of parenteral and inhalative therapy with Mucosolvan has proved effective as intensive therapy. Therapy can then be continued with oral dosage forms .

Mucosolvan /Ambroxol Adverse Reactions

Mucosolvan is generally well tolerated. rare cases of hypersensitivity reactions have been reported and in single cases acute anaphylactic-type signs of shock. The following signs have been observed: skin reactions and/or mucosal reactions, swelling of the face, dyspnea, rise in temperature with chills, gastrointestinal complaints have been reported in very rare cases.

Mucosolvan /Ambroxol Contra Indications

Known hypersensitivity to ambroxol.

Mucosolvan /Ambroxol Drug Interactions

Administration of ambroxol together with antibiotics (amoxicillin, cefuroxime, erythromycin and doxycycline) leads to antibiotic concentration in lung tissue. No clinically relevant unfavorable interaction with other medication have been reported.

---

Mucosolvan 30 mg/Tablet

Each tablet contains 30 mg Ambroxol HCl

Company Name
CID/Boehringer

Pharmaceutical form
Tablet

Package

Box of 20 tablets (2 strips each contains 10 tablets).

Indications

- Secretolytic therapy in acute and chronic bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport, such as acute exacerbation of chronic bronchitis, bronchiectasis, asthmoid bronchitis and bronchial asthma. - In pre- and post operative treatment.

Warning & Precautions

- Preclinical studies as well as extensive clinical experience after the 28th week have shown no evidence of ill-effects during pregnancy. Nonetheless, the usual precautions regarding the use of drugs during pregnancy, especially during the first trimester, should be observed. - The drug enters breast milk, but is not likely to affect the infant when therapeutic doses are used. - Mucosolvan solution contains the preservative benzalkonium chloride. It has been reported that this preservative may cause bronchoconstriction on some patients with hyper-reactive airways.

Product Type

human

Dosage

- Mucosolvan tablets: Adults: 1 tablet 3 times daily. In long-term therapy, the dose may be reduced to twice daily. The tablets should be taken after meals with liquid.

Adverse Reactions

Mucosolvan is generally well tolerated. rare cases of hypersensitivity reactions have been reported and in single cases acute anaphylactic-type signs of shock. The following signs have been observed: skin reactions and/or mucosal reactions, swelling of the face, dyspnea, rise in temperature with chills, gastrointestinal complaints have been reported in very rare cases.

Contra Indications

Known hypersensitivity to ambroxol.

Drug Interactions
Administration of ambroxol together with antibiotics (amoxicillin, cefuroxime, erythromycin and doxycycline) leads to antibiotic concentration in lung tissue. No clinically relevant unfavorable interaction with other medication have been reported.

---

Mucosolvan Drops

Each 2 ml contains 15 mg. Ambroxol Hcl

Company Name
CID/Boehringer

Therapeutic Group
EXPECTORANTS

Pharmaceutical form
Drops

Package
Glass bottle of 40 ml solution.

Indications
- Secretolytic therapy in acute and chronic bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport, such as acute exacerbation of chronic bronchitis, bronchiectasis, asthmoid bronchitis and bronchial asthma. - In pre- and post operative treatment.

Warning & Precautions
- Preclinical studies as well as extensive clinical experience after the 28th week have shown no evidence of ill-effects during pregnancy. Nonetheless, the usual precautions regarding the use of drugs during pregnancy, especially during the first trimester, should be observed. - The drug enters breast milk, but is not likely to affect the infant when therapeutic doses are used. - Mucosolvan solution contains the preservative benzalkonium chloride. It has been reported that this preservative may cause bronchoconstriction on some patients with hyper-reactive airways.

Product Type
human

Dosage
-The recommendations for children are based on a total daily dose of 1.2-1.6 mg/kg b.wt. unless otherwise pescribed. Mucosolvan solution (15mg/2ml) for oral or inhalation use: Oral (1 ml = 25 drops): Adults: at the initiation of treatment 4 ml 3 times daily. In long term treatment, the dose may be reduced to 2 ml 3 times daily . Children over 5 years: 2ml (50 drops) 2-3 times daily. Children 2-5 years: 1ml (25 drops) 3 times daily. Children under 2 years: 1ml (25 drops) twice daily. The drops should be taken with meals diluted with tea, fruit juice, milk or water . Inhalation: Adult and Children over 5 years: 1-2 inhalations of 2-3 ml solution daily. Children under 5 years: 1-2 inhalations of 2 ml solution daily . N.B. - Should only one inhalation per day be possible, a sustained action can be achieved by the supplementary administration of tablets or liquid . - Mucosolvan inhalant solution can be used in all modern inhalation devices (excluding steam inhalers). It is miscible with physiological saline solution and may be diluted 1:1 in order to obtain optimal moisturisation of the respiratory air in a respirator. - Since deep inhalation may provoke a cough impulse, the patient should breathe normally during the inhalation treatment. - Warming the solution to body temperature before inhalation is recommended for sensitive patients. - Patients with bronchial asthma should use a bronchospasmolytic before commencing inhalation.

Adverse Reactions
Mucosolvan is generally well tolerated. rare cases of hypersensitivity reactions have been reported and in single cases acute anaphylactic-type signs of shock. The following signs have been observed: skin reactions and/or mucosal reactions, swelling of the face, dyspnea, rise in temperature with chills, gastrointestinal complaints have been reported in very rare cases.

Contra Indications
Known hypersensitivity to ambroxol.

Drug Interactions
Administration of ambroxol together with antibiotics (amoxicillin, cefuroxime, erythromycin and doxycycline) leads to antibiotic concentration in lung tissue. No clinically relevant unfavorable interaction with other medication have been reported.

---

Mucosolvan Syrup

Each 5 ml contains: Ambroxol HCl 15 mg

Company Name
CID/Boehringer

Therapeutic Group
EXPECTORANTS

Pharmaceutical form
Syrup

Package
Glass bottle of 100 ml liquid.

Indications
- Secretolytic therapy in acute and chronic bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport, such as acute exacerbation of chronic bronchitis, bronchiectasis, asthmoid bronchitis and bronchial asthma. - In pre- and post operative treatment.

Warning & Precautions
- Preclinical studies as well as extensive clinical experience after the 28th week have shown no evidence of ill-effects during pregnancy. Nonetheless, the usual precautions regarding the use of drugs during pregnancy, especially during the first trimester, should be observed. - The drug enters breast milk, but is not likely to affect the infant when therapeutic doses are used. - Mucosolvan solution contains the preservative benzalkonium chloride. It has been reported that this preservative may cause bronchoconstriction on some patients with hyper-reactive airways.

Product Type
human

Dosage
The recommendations for children are based on a total daily dose of 1.2-1.6 mg/kg b.wt. unless otherwise prescribed : - Mucosolvan liquid (15 mg / 5 ml): Adults and children over 12 years: 10 ml ( 2 measuring cups ) 3 times daily for the first 2-3 days. Later, 5 ml (1 measuring cup) 3 times daily . Children 5 - 12 years: 5 ml (1 measuring cup) 2-3 times daily . Children 2 - 5 years: 2.5 ml ( ½ measuring cup) 3 times daily Children under 2 years : 2.5 ml ( ½ measuring cup) twice daily . The above regimen are suitable for the therapy of acute respiratory tract disorders and for the initial treatment of chronic conditions up to 14 days. In longer treatment the dose can be halved. Mucosolvan liquid should be taken at meal times .

Adverse Reactions
Mucosolvan is generally well tolerated. rare cases of hypersensitivity reactions have been reported and in single cases acute anaphylactic-type signs of shock. The following signs have been observed: skin reactions and/or mucosal reactions, swelling of the face, dyspnea, rise in temperature with chills, gastrointestinal complaints have been reported in very rare cases.

Contra Indications
Known hypersensitivity to ambroxol.

Drug Interactions
Administration of ambroxol together with antibiotics (amoxicillin, cefuroxime, erythromycin and doxycycline) leads to antibiotic concentration in lung tissue. No clinically relevant unfavorable interaction with other medication have been reported.

Search Post

Label :

Effortil | Etilefrine-HCL ( Ethyl Adrinol)

Effortil Tablets

Each tablets contains : 5 mg Etilefrine-HCL

 ( Ethyl Adrinol)

Company Name
CID/Boehringer

Therapeutic Group
CARDIAC STM EX DOPAM AGTS

Pharmaceutical form
Tablets

Package
Boxes of 20 tablets (2 strips each contains 10 tablets).

Indications
- Circulatory failure, circulatory collapse in comatose conditions, during and after infectious diseases, myocardial infarction, surgery, parturition, accidents, conditions arising from intoxication , tumor cachexia, hypotension, hypotensive circulatory disorders, orthostatic dysregulation . - In constitutional asthenia, chronic infectious diseases, during convalescence, after surgery and parturition, during pregnancy and the years of growth. - Prevention of circulatory incidents in minor diagnostic and therapeutic interventions, certain types of vasomotor headache, tendency to collapse associated with the dumping syndrome, oversensitivity to weather.

Product Type
human

Dosage
Adults: 0.5 - 1 tablet, 3 times a day. Children: 0.5 - 1 tablet, 2-3 times a day. Dosage must be adjusted to the individual requirements of the patient, dependent upon the response of blood pressure and pulse rate. **Effortil may be taken with water before or after meals. **For children, drops or tablets are best dissolved in a teaspoonful of sugar- water.

Adverse Reactions

Contra Indications
Thyrotoxicosis.

Drug Interactions

---

Effortil Drops

Solution containing: 7.5 mg/g Etilefrine-HCL (Ethyl Adrinol)

Company Name
CID/Boehringer

Therapeutic Group
CARDIAC STM EX DOPAM AGTS

Pharmaceutical form
Drops

Package
Bottles of 15 gm.

Indications
- Circulatory failure, circulatory collapse in comatose conditions, during and after infectious diseases, myocardial infarction, surgery, parturition, accidents, conditions arising from intoxication , tumor cachexia, hypotension, hypotensive circulatory disorders, orthostatic dysregulation . - In constitutional asthenia, chronic infectious diseases, during convalescence, after surgery and parturition, during pregnancy and the years of growth. - Prevention of circulatory incidents in minor diagnostic and therapeutic interventions, certain types of vasomotor headache, tendency to collapse associated with the dumping syndrome, oversensitivity to weather.

Product Type
human

Dosage
Adults: 3 - 6 drops, 3 times a day. Children: 3 - 6 drops, 2-3 times a day. Babies: 1 - 3 drops, 2-3 times a day. Dosage must be adjusted to the individual requirements of the patient, dependent upon the response of blood pressure and pulse rate. **Effortil may be taken with water before or after meals. **For children, drops or tablets are best dissolved in a teaspoonful of sugar- water.

Adverse Reactions

Contra Indications
Thyrotoxicosis.

Drug Interactions

Search Post

Label :

Dulcolax 5 mg | Bisacodyl

Dulcolax 5 mg

Each coated tablet contains 5 mg Bisacodyl

Company Name
CID/Boehringer

Pharmaceutical form
Tablet

Package
Boxes of 20 or 200 or 500 tablets (2 or 20 or 50 strips each contains 10 tablets)

Indications
For use in patients suffering from constipation, in preparation for diagnostic procedures, in pre- and postoperative treatment and in conditions which require defecation to be facilitated. DULCOLAX Should be used under medical supervision.

Warning & Precautions
- As with all laxatives, DULCOLAX should not be taken on a continuous daily bases for long periods. if laxatives are needed every day, the cause of constipation should be investigated. Prolonged excessive use may lead to fluid and electrolytes imbalance and hypokalaemia and may precipitate onset of rebound constipation. - Dizziness and/or syncope have been reported in patients who have taken DULCOLAX. the details available for these cases suggest that the events would be consistent with defecation syncope (or syncope attributable to straining at stool), or with a vasovagal response to abdominal pain which may be related to the constipation that prompted the patient in question to response to the use of laxatives and not necessarily to the administration of DULCOLAX itself. - Children should not take DULCOLAX without medical advice. - Long experience has shown no evidence of undesirable or damaging effects during pregnancy. Nevertheless, as with all drugs, DULCOLAX should only be taken during pregnancy on medical advise. - Whether Bisacodyl passes into breast milk has not been established, breast feeding during DULCOLAX treatment is therefore not recommended.

Product Type
human

Dosage
Recommended intake unless otherwise prescribed by physician, the following dosages are recommended: For constipation: Coated tablets: Adults and children over 10 years: 1-2 coated tablets (5-10 mg). Children 4-10 years: 1 tablet (5 mg) The tablets should be taken at night to produce evacuation in the following morning. They should be swallowed whole with adequate fluid. The tablets should not be taken together with milk or antacids. For preparation for diagnostic procedures and preoperatively: When using DULCOLAX to prepare the patient for radiographic examination of the abdomen or preoperatively, tablets should be combined with the suppositories in order to achieve complete evacuation of the intestine. The dosage recommended for adults is (2-4) tablets at the night before and 1 suppository to be inserted in the following morning. In case of children of four years of age and over, 1 tablet in the evening and 1 pediatric suppository in the following morning is recommended.

Adverse Reactions
While using DULCOLAX, episodes of abdominal discomfort including cramps and abdominal pain may occur. diarrhea has been observed. allergic reactions including isolated cases of angioedema and anaphylactoid reactions have been reported in association with the administration of DULCOLAX.

Contra Indications
DULCOLAX is contraindicated in patients with ileus, intestinal obstruction, acute surgical abdominal conditions including appendicitis, acute inflammatory bowel diseases, and in severe dehydration. It is also contraindicated in patients with known hypersensitivity to Bisacodyl or any other component of the product.

Drug Interactions
The concomitant use of diuretics or adrenocorticosteroids may increase the risk of electrolyte imbalance if excessive doses of DULCOLAX are taken. Electrolyte imbalance may lead to increased sensitivity to cardiac glycosides.

Search Post

Label :

Buscopan Plus Adult Supp.

Buscopan Plus Adult Supp.

1 suppository contains: Hyoscine-N-butylbromide 10mg Paracetamol 800mg

Company Name
CID/Boehringer

Therapeutic Group
ANTISPASM\ANALGESIC COMBS

Pharmaceutical form
Suppository

Package
Box of 5 suppositories.

Indications
Paroxysmal pain in diseases of the stomach or intestine, spastic pain and functional disorders in the biliary and urinary tracts and female genital organs (e.g. dysmenorrhoea).

Warning & Precautions
Buscopan Plus should be used with caution in: -- Hepatic dysfunction (e.g. due to chronic alcohol abuse, hepatitis) -- Renal dysfunction -- Gilblert’s syndrome ( Meulengracht's disease) In such cases Buscopan Plus should only be used under medical supervision and, if necessary, the dose reduced or the intervals between the individual administrations prolonged . Pregnancy and lactation: Available but limited preclinical data has shown no hazard, but safety during human pregnancy has not yet been established .The usual precautions regarding the use of drugs at this time, especially during the first trimester, should be observed. Hyoscine-N-butylbromide safety during lactation has not yet been established . The active ingredient paracetamol enters breast milk, but is not likely to affect the infant when therapeutic doses are used .

Product Type
human

Dosage
Unless otherwise prescribed by the physician: For Adults: 1 suppository introduced into the rectum 3 to 4 times daily. The total daily dose should not exceed 4 suppositories. Buscopan Plus should not be taken over a prolonged period of time or in higher doses without a prescription from the doctor or dentist. The film-coated tablets and the suppositories are not suitable for children.

Adverse Reactions
Following administration of Buscopan Plus rubefaction may occur in rare cases, allergic reactions with exanthema in very rare cases, allergic platelet deficiency (thrombocytopenia) or reduction in leucocytes ( leucopenia ) in extremely rare cases. A reduction in granulocytes in the blood (agranulocytosis) or a reduction in cellular blood elements (pancytopenia) have been described in isolated cases in connection with paracetamol. Spasms of the bronchial muscles in the case of asthma (bronchospasm) may occur in predisposed patients (analgesic-induced asthma) in isolated cases. In Buscopan Plus overdosage there is a risk of severe liver damage due to paracetamol.

Contra Indications
-- Known genetically determined glucose-6-phosphate dehydrogenase deficiency. -- Known hypersensitivity to paracetamol.

Drug Interactions
Otherwise harmless doses of paracetamol may cause liver damage if taken together with drugs leading to enzyme induction such as certain hypnotics and anti-epileptics (e.g. glutethimide, phenobarbital, phenytoin, carbamazepin) as well as rifampicin. The same applies to alcohol abuse. Where gastric emptying is slowed down, as for instance with propantheline, the absorption rate of paracetamol may be reduced with the result that onset of action is delayed. Acceleration of gastric emptying, e.g. after administration of metoclopramide, leads to an increase in the absorption rate. Combination with chloramphenicol can prolong the half-life with the risk of increased toxicity. The clinical relevance of interactions between paracetamol and warfarin as well as coumarin derivatives cannot yet be assessed. Therefore, long-term use of paracetamol in patients being treated with oral anticoagulants is only advisable under medical supervision.

Search Post

Label :

Buscopan Plus Tablets

Buscopan Plus Tablets

1 film-coated tablet contains: Hyoscine-N-butyibromide 10mg Paracetamol 500mg

Company Name
CID/Boehringer

Therapeutic Group
ANTISPASM\ANALGESIC COMBS

Pharmaceutical form
Tablet

Package
Box of 20 tablets (2 strips of 10 tablets each)

Indications
Paroxysmal pain in diseases of the stomach or intestine, spastic pain and functional disorders in the biliary and urinary tracts and female genital organs (e.g. dysmenorrhoea).

Warning & Precautions
Buscopan Plus should be used with caution in: - Hepatic dysfunction (e.g. due to chronic alcohol abuse, hepatitis) -- Renal dysfunction -- Gilblert’s syndrome ( Meulengracht's disease) In such cases Buscopan Plus should only be used under medical supervision and, if necessary, the dose reduced or the intervals between the individual administrations prolonged . Pregnancy and lactation: Available but limited preclinical data has shown no hazard, but safety during human pregnancy has not yet been established .The usual precautions regarding the use of drugs at this time, especially during the first trimester, should be observed. Hyoscine-N-butylbromide safety during lactation has not yet been established . The active ingredient paracetamol enters breast milk, but is not likely to affect the infant when therapeutic doses are used .

Product Type
human

Dosage
Unless otherwise prescribed by the physician: For Adults: 1-2 tablets three times daily, swallowed whole with a little liquid. The total daily dose should not exceed 6 tablets. Buscopan Plus should not be taken over a prolonged period of time or in higher doses without a prescription from the doctor or dentist. The film-coated tablets are not suitable for children.

Adverse Reactions
Following administration of Buscopan Plus rubefaction may occur in rare cases, allergic reactions with exanthema in very rare cases, allergic platelet deficiency (thrombocytopenia) or reduction in leucocytes ( leucopenia ) in extremely rare cases. A reduction in granulocytes in the blood (agranulocytosis) or a reduction in cellular blood elements (pancytopenia) have been described in isolated cases in connection with paracetamol. Spasms of the bronchial muscles in the case of asthma (bronchospasm) may occur in predisposed patients (analgesic-induced asthma) in isolated cases. In Buscopan Plus overdosage there is a risk of severe liver damage due to paracetamol.

Contra Indications
-- Known genetically determined glucose-6-phosphate dehydrogenase deficiency. -- Known hypersensitivity to paracetamol.

Drug Interactions
Otherwise harmless doses of paracetamol may cause liver damage if taken together with drugs leading to enzyme induction such as certain hypnotics and anti-epileptics (e.g. glutethimide, phenobarbital, phenytoin, carbamazepin) as well as rifampicin. The same applies to alcohol abuse. Where gastric emptying is slowed down, as for instance with propantheline, the absorption rate of paracetamol may be reduced with the result that onset of action is delayed. Acceleration of gastric emptying, e.g. after administration of metoclopramide, leads to an increase in the absorption rate. Combination with chloramphenicol can prolong the half-life with the risk of increased toxicity. The clinical relevance of interactions between paracetamol and warfarin as well as coumarin derivatives cannot yet be assessed. Therefore, long-term use of paracetamol in patients being treated with oral anticoagulants is only advisable under medical supervision.

Search Post

Label :

Buscopan Compositium ampoules / Tablets

Buscopan Compositium ampoules

Buscopan Compositium ampoule.

Each ampoule (5 ml) contains:

 Hyoscine-N-butyl Bromide 20 mg and dipyrone 2500 mg.

Company Name
CID/Boehringer

Therapeutic Group
ANTISPASM\ANALGESIC COMBS

Pharmaceutical form
Ampoule

Package
Box of 3 ampoules, each of 5 ml.

Buscopan Indications - uses

Buscopan compositum is mainly indicated in:
- Intestinal, renal and biliary colics.
- Post operative vomiting.
- Analgesic: For pain of different etiologies as : Sciatica, Lumbago, Headache, Neuralgia, Toothache.
- Antirheumatic: Rheumatic arthritis both acute and chronic, Rheumatic myositis and fibrositis, Spondylitic conditions.
- It is also used as an adjuvant to smooth muscle relaxant.

Buscopan Warning & Precautions

* Buscopan compositum should be given with cautious in the following cases: - Bronchial asthma or chronic respiratory infections. - Hypersensitive patients. - Heamatopoietic disorders. * Pregnancy & lactation: It must be used cautiously in pregnancy and lactation. * As with the pyrazolone derivatives, hypersensitivity reactions and disturbances in the white blood cells count may rarely occur during treatment with this drug. white blood cells counts must be performed if patients on prolonged therapy with metamizole complain of tiredness . Treatment should be discontinued if granulocytopenia occur.

Product Type
human

Buscopan Dosage

The usual dose to relieve spastic pain in disorders of the gastrointestinal, renal and biliary colics is :2ml to be administered by slow I.V administration, and it can be administered by intramuscularly if I.V administration is not available, but avoid S.C administration.

Buscopan Adverse Reactions

- Gastro intestinal: dryness of mouth, constipation and vomiting may occasionally occur.
- Cardiovascular: tachycardia may occur.
- Idiosyncratic reactions may occur.
- Hyoscine cross the blood brain barrier and cause sedation.

Buscopan Contra Indications - side effects

- Hypersensitivity to anticholinergic drugs or any of drug components: patients hypersensitive to belladonna or to barbiturates may be hypersensitive to hyoscine.
- Narrow angle glaucoma, adhesions between the iris and lens.
- Cardiovascular: tachycardia, myocardial ischemia.
- Gastro intestinal obstructive disease, paralytic ileus, ulcerative colitis, hepatic diseases.
- Genito urinary system: obstructive uropathy, renal diseases, enlarged prostate.

Buscopan Drug Interactions

- Antihistaminics increase antimuscarinic side effect of hyoscine. .
- Metoclopramide and domperidone: antimuscranics antagonise gastro-intestinal effects of hyoscine..
- Parasympathomimetics antagonise the effect of hyoscine.

---

Buscopan Compositium Tablet. 

Each sugar-coated tablets contains: Hyoscine-N-butyl Bromide 10 mg and dipyrone 250 mg

Company Name

CID/Boehringer

Therapeutic Group
ANTISPASM\ANALGESIC COMBS

Pharmaceutical form
Tablet

Package
Box of 20 tablets

Indications - uses

Buscopan compositum is mainly indicated in:
- Life threatening pain.
- Severe cases of intestinal, renal and biliary colics.
- Post operative vomiting.

Warning & Precautions

* Buscopan compositum should be given with caution in the following cases: - Bronchial asthma or chronic respiratory infections. - Hypersensitive patients. - Heamatopoietic disorders. * Pregnancy &lactation: It must be used cautiously in pregnancy and lactation. * As with the pyrazolone derivatives, hypersensitivity reactions and disturbances in the white blood cells count may rarely occur during treatment with this drug. white blood cells counts must be performed if patients on prolonged therapy with Metamizole complain of tiredness . Treatment should be discontinued if granulocytopenia occur.

Product Type
human

Dosage

The usual dose to relieve spastic pain in disorders of the gastrointestinal, renal and biliary colics is (1 – 2) tablets if necessary maximum 4 tablets daily until pain is relieved. the tablet should be swallowed whole.

Adverse Reactions 

- Gastro intestinal tract: dryness of mouth, constipation and vomiting may occasionally occur.
- Cardiovascular system: tachycardia may occur.
- Idiosyncratic reactions may occur.
- Hyoscine cross the blood brain barrier and cause sedation.

Drug Contraindications - side effects

- Hypersensitivity to anticholinergic drugs or any of drug components: patients hypersensitive to belladonna or to barbiturates may be hypersensitive to hyoscine.
- Narrow angle glaucoma, adhesions between the iris and lens.
- Cardiovascular disorders: tachycardia, myocardial ischemia.
- Gastro intestinal obstructive disease, paralytic ileus, ulcerative colitis, hepatic diseases.
- Genito urinary disorders: obstructive uropathy, renal diseases, enlarged prostate.

Drug Interactions

* Antihistaminics increase antimuscarinic side effect of hyoscine.
* Metoclopramide and domperidone: antimuscranics antagonise gastro -intestinal effects of hyoscine.
* Parasympathomimetics antagonise the effect of hyoscine.

Search Post

Label :

Buscopan | Hyoscine-N-butyl bromide

Buscopan 10mg tab.
- Each sugar coated tablet contains: Hyoscine –N – butylbromide 10mg.


Company Name
CID/Boehringer

Pharmaceutical form
Tablet

Package
Buscopan sugar coated tablets: Box of 20 tablets

Indications
- Gastro intestinal spasm and hypermotility , pylorospasm in infants, post- operative vomiting , spastic constipation , biliary dyskinesia and spasm of the urinary tract . - Delayed relaxation of the lower uterine segment , dysmenorrhoa .


Product Type
human

Dosage
Adults and school children:
The usual dose is 1-2 sugar coated tablets (each containing 10 mg) administered 3 – 5 times daily .The dose can be raised at the discretion of the physician . The tablets should be swallowed whole with a little water.
In more pronounced conditions of pain 1 ampoule containing 20 mg may be injected subcutaneously, intramuscularly or intravenously several times daily. In severe biliary and renal colic the slow intravenous injection of Buscopan compositum rapidly relieves the severe pain.

Adverse Reactions

Contra Indications

Drug Interactions

---

Buscopan 20mg/Ampoule

Each ampoule contains: Hyoscine-N-butyl bromide 20 mg


Company Name
CID/Boehringer

Therapeutic Group
ANTISPASM+ANTICHOL PLAIN

Pharmaceutical form
Ampoule

Package
Box of 6 ampoules

Indications
- Gastro intestinal spasm and hypermotility , pylorospasm in infants, post- operative vomiting , spastic constipation , biliary dyskinesia and spasm of the urinary tract . - Delayed relaxation of the lower uterine segment , dysmenorrhoa .

Product Type
human

Dosage
Adults and school children: In more pronounced conditions of pain 1 ampoule containing 20 mg may be injected subcutaneously, intramuscularly or intravenously several times daily. In severe biliary and renal colic the slow intravenous injection of Buscopan compositum rapidly relieves the severe pain. Infants and young children: In severe case: 1/4 of an ampoule 3 times daily.

Adverse Reactions

Contra Indications

Drug Interactions

Search Post

Label :

Bisolvon Drops | Bromhexine HCl.

Bisolvon Drops
Each 2 ml solution contains 4 mg of Bromhexine HCl.

Company Name
CID/Boehringer

Therapeutic Group
EXPECTORANTS

Pharmaceutical form
Drops

Package
Bottle of 40 ml

Indications
All forms of tracheobronchitis, emphysema with bronchitis, pneumoconiosis, chronic inflammatory pulmonary conditions, bronchiectasis, bronchitis with bronchospasm, asthma. During acute exacerbations of bronchitis, Bisolvon should be given with the appropriate antibiotic . Bisolvon may also be administered to facilitate and expedite the expectoration of abnormal fluid present in the bronchi e.g. contrast media.

Warning & Precautions
- Studies in animals have given no suggestion that Bisolvon has any teratogenic potential in humans nevertheless as with any drug, it is advisable to avoid use during the first trimester of pregnancy. - Patients being treated with Bisolvon should be warned to expect an increase in the flow of secretions.


Product Type
human

Dosage
1. Oral: Solution 8mg/4ml (60 drops=4ml): - For Adults and children over 10 years : 4 ml t.i.d. - For Children 5-10 year: 2ml t.i.d. - For Children under 5 years: 20 drops t.i.d. - For babies: 10 drops t.i.d. At the commencement of treatment it may be necessary to increase or double the dose. 2. Inhalation (with aerosol apparatus): For sensitive patients it is advisable to warm the solution to body temperature to prevent possible initial irritative cough. Before inhalation in bronchial asthma or with asthmatic symptoms a bronchodilator (e g. Aludrin or Alupent) should first be administered Solution (diluted in water 1:1) - Adults : 2 ml 2-3 times daily. - Children over 10 years: 2 ml 1-2 times daily. - Children 5-10 years: 1 ml twice daily. - Children under 5 years: 10 drops twice daily. - Babies: 5 drops twice daily. The combined administration of inhalation and oral application intensifies the effect and is especially suited for the commencement of treatment in cases where the full effect is to be reached quickly.

Adverse Reactions
Occasional gastro-intestinal side effects may occur but these are almost invariably mild.

Contra Indications
Bisolvon should not be administered to patients with hypersensitivity to bromhexine.

Drug Interactions

Search Post

Label :

Bisolvon 4mg/Ampoule | Bromhexine HCl

Bisolvon 4mg/Ampoule

Each ampoule of 2 ml contains 4 mg , of Bromhexine HCl.

Company Name

CID/Boehringer

Therapeutic Group

EXPECTORANTS

Pharmaceutical form

Ampoule

Package

Box of 5 ampoules

Bisolvon Indications

All forms of tracheobronchitis, emphysema with bronchitis, pneumoconiosis, chronic inflammatory pulmonary conditions, bronchiectasis, bronchitis with bronchospasm, asthma. During acute exacerbations of bronchitis, Bisolvon should be given with the appropriate antibiotic . Bisolvon may also be administered to facilitate and expedite the expectoration of abnormal fluid present in the bronchi e.g. contrast media.

Bisolvon Warning & Precautions

*Studies in animals have given no suggestion that Bisolvon has any teratogenic potential in humans nevertheless as with any drug, it is advisable to avoid use during the first trimester of pregnancy. *Patients being treated with Bisolvon should be warned to expect an increase in the flow of secretions .

Product Type

human

Bisolvon Dosage

Ampoules for injection (4mg. in 2ml): The administration of Bisolvon ampoules is recommended for the treatment of the most severe cases as well as for reducing postoperative complications. In severe cases as well as before and after surgical interventions 1 ampoule S.C., I.M. or I.V. (duration of injection 2- 3 minutes) 2 -3 times daily. The injection solution can also be given as a drip infusion together with glucose, levulose, or Ringer’s solution. Bisolvon should not be mixed with alkaline solutions as the acid character of Bisolvon solution (pH 2.8) may cause cloudiness or flocculation.

Bisolvon Adverse Reactions

Occasional gastro-intestinal side effects may occur but these are almost invariably mild.

Bisolvon Contra Indications

Bisolvon should not be administered to patients with hypersensitivity to bromhexine.

Bisolvon Drug Interactions

Search Post

Label :

Berotec | Fenoterol hydrobromide For prophylaxis and bronchospasm

Berotec | Fenoterol hydrobromide

Berotec 2.5 mg/5ml

Each 5ml (=1 measuring cap) liquid contains: Fenoterol hydrobromide 2.5mg

Company Name

CID/Boehringer - Egypt

Therapeutic Group

B2-STIMULANTS. SYSTEMIC

Pharmaceutical form

Syrup

Package
Liquid: Bottles of 100 ml.

Berotec Indications

For the prophylaxis and treatment of bronchospasm in bronchial asthma,
obstructive bronchitis , chronic bronchitis , emphysema and bronchopulmonary disorders with bronchospasm (silicosis , bronchiectasis, tuberculosis , bronchial carcinoma) and bronchospasm in infants

Berotec Warning & Precautions

* As with all other drugs during the first three months of pregnancy Berotec should only be used after consultation with the doctor. The same precautions should be taken shortly before childbirth because of the uterine muscles relaxant effect of Berotec. * Simultaneous therapy with other bronchodilators should only be carried out on the physician's specific orders. If therapy does not produce the desired effect , then the pathological condition is not responding sufficiently well to therapy because of the involvement of other factors. Immediate medical advice should therefore be sought in order that a new plan of treatment can be determined .

Product Type

human

Berotec Dosage

The individual dosage is determined by the physician before commencement of treatment, patients should be kept under medical observation during treatment .The dosage can be increased or reduced according to the individual response and the degree of the disease .
Berotec Syrup:
For Adults: 1-2 measuring caps, three times daily.
For School children (6-14 years): one measuring cap, three to four times daily.
For Small children (1-6 years): ½ -1 measuring cap, three times daily.
For Infants (up to 1year): ½ measuring cap, two to three times daily.Berotec should be taken before meals and only in sensitive patients after meals .Berotec liquid can be used by patients with diabetes without restrictions of diet .

Berotec Adverse Reactions

Berotec is well tolerated. In cases where the autonomic system is particularly sensitive , restlessness and palpitations may occur briefly and there may be fine tremor of the fingers. Dizziness, fatigue, headache and sweating have also been observed. If these side effects occur the dose should reduced .

Berotec Contra Indications

Idiopathic hypertrophic aortic stenosis, thyrotoxicosis ,tachyarrhythmia .
Use of Berotec in patients with recent myocardial infarction and/or severe organic heart or vascular alterations especially in doses exceeding the recommended levels should only be undertaken upon medical advice

Drug Interactions

B-receptor blocker in adequate doses counteract the action of Berotec.

Search Post

Label :

Rigaminol | Gentamycin for bacterial indections

Rigaminol 20 mg
Each ampoule containing 20 mg Gentamycin ( as Sulphate)

Company Name
CID/Atral

Therapeutic Group
AMINOGLYCOSIDES

Pharmaceutical form
Ampoule

Package
Box of 3 ampoule, each of 0.5 ml

Indications
Is indicated in infections produced by sensitive Gram - positive and Gram- negative bacteria. Particularly those refered to in the text. Clinical papers register a multiplicity of situations where this product has given excellent results : urogenital, respiratory, peritoneal infections , sepsis, meningitis, encephalitis , otorhinolaryngologic and dermatologic infections.

Warning & Precautions
The risks of an increase of concentration due to renal dysfunction are to be expected. In the case of eventual vestibular damage precaution must be taken in relation to the use of gentamicin.


Product Type
human

Dosage
To be taken under medical supervision. As a rule it is recommended : CHILDREN: The recommended daily dosage is 3 to 5 mg/kg of body weight divided into 3 administrations (at 8 hours intervals )and should be cut down as soon as it is clinically advisable. For the premature infants and for the term new – born babies until one week of age the advised daily dosage is 6 mg/kg administered every 12 hours intervals .After one week age, this daily dosage can be administered in 3 injections at 8 hours intervals. NOTE: When an intravenous route is necessary, isotonic saline solution or a 5% dextrose solution are advised. GENTAMICIN’S final concentration should not exceed 1mg/kg ( 0. 1% ) the solution should be administered over a period of 1 to 2 hours.

Adverse Reactions
Contra Indications
Drug Interaction

Search Post

Label :

Bricanyl 2.5 mg | Terbutaline sulphate for onchial asthma, chronic bronchitis, emphysema and other lung diseases

Bricanyl 2.5 mg
1 tablet contains: Terbutaline sulphate 2.5 mg.

Company Name
CID/AstraZeneca

Pharmaceutical form
Tablet

Package
Box of 20 tablets .

Indications
Bronchial asthma, chronic bronchitis, emphysema and other lung diseases where bronchospasm is a complicating factor.

Warning & Precautions
- As for all B2-agonists caution should be observed in patients with thyrotoxicosis and in patients with severe cardiovascular disorder, such as ischemic heart disease, tachyarrhythmias or severe heart failure. - Due to the hyperglycemic effects of B2-agonists, additional blood glucose controls are recommended initially in diabetic patients. - Potentially serious hypokalemia may result from B2-agonist therapy. Particular caution is recommended in acute severe asthma as the associated risk may be augmented by hypoxia. The hypokalemic effect may be potentiated by concomitant treatments (see “Interactions”). It is recommended that serum potassium levels are monitored in such situations. - Use during pregnancy and lactation: * No teratogenic effects have been observed in patients or in animals. However, caution is recommended during the first trimester of pregnancy. * Terbutaline passes over to breast milk but an influence on the child is unlikely with therapeutic doses. * Transient hypoglycemia has been reported in newborn preterm infants after maternal B2-agonist treatment.

Product Type
human

Dosage


Bricanyl tablets should be used as maintenance therapy in asthma and other pulmonary diseases where bronchospasm is a complicating factor. Dosage should be individual. Adults: During the first 1-2 weeks: 2.5 mg 3 times in a 24 h period is recommended. The dose may then, if necessary, be increased to 5 mg 3 times in 24 hours. Children: 0.075 mg/kg body weight 3 times in 24 hours. Suitable dosage:

< 20 kg : ¼ - ½ tablets 3 times in 24 hours. 20- 30 kg : ½ - 1 tablets 3 times in 24 hours.
>30 kg: 1-2 tablets 3 times in 24 hours

Adverse Reactions
- The intensity of the adverse reactions depends on dosage and route of administration. An initial dose titration will often reduce the adverse reactions. Adverse reactions which have been recorded, e.g. tremor, headache, nausea, tonic muscle cramps, tachycardia and palpitations, are all characteristic of sympathomimetic amines. The majority of these effects have reversed spontaneously within the first 1-2 weeks of treatment. - As for all B2-agonists, cardiac arrhythmias, e.g. atrial fibrillation, supraventricular tachycardia and extrasystoles have been rarely reported. - Urticaria and exanthema may occur. - Sleep disturbances and behavioural disturbances, such as agitation, hyperactivity and restlessness, have been observed. - Bricanyl does not affect the ability to drive or use machines.

Contra Indications
Hypersensitivity to any of the ingredients.

Drug Interactions
- Beta-receptor blocking agents (including eye-drops), especially those which are non-selective, may partly or totally inhibit the effect of beta-receptor stimulants. - Hypokalemia may result from B2-agonist therapy and may be potentiated by concomitant treatment with xanthine derivatives, steroids and diuretics (see “Special warnings and precautions for use”).

Search Post

Label :

Betaloc 100mg | metoprolol tartrate

Betaloc 100 mg
Each tablet contains metoprolol tartrate 100 mg.

Company Name
CID/AstraZeneca

Therapeutic Group
BETA BLOCKING AGENT PLAIN

Pharmaceutical form
Tablet

Package
Box of 20 tablets

Indications
- Hypertension: to reduce blood pressure and to reduce the risk of cardiovascular and coronary mortality (including sudden death), and morbidity. - Angina pectoris. - Disturbances of cardiac rhythm including especially supraventricular tachycardia. - Maintenance treatment after myocardial infarction. - Functional heart disorders with palpitations. - Migraine prophylaxis. - Hyperthyroidism.

Warning & Precautions
- Intravenous administration of calcium antagonists of the verapamil-type should not be given to patients treated with β-blockers. - Generally when treating patients with asthma, concomitant therapy with a β2-agonist (tablet and/or inhalation) should be administered. The dosage of β2-agonists may require adjustment (increase) when treatment with Betaloc is started. - During treatment with Betaloc, the risk of interfering with carbohydrate metabolism or masking hypoglycaemia is less than with nonselective β-blockers. - Patients suffering from heart failure should have their decompensation treated both before and during treatment with Betaloc. - Very rarely, a pre-existing A-V conduction disorder of moderate degree may become aggravated (possibly leading to A-V block). - If the patients develop increasing bradycardia, Betaloc should be given in lower doses or gradually withdrawn. - Betaloc may aggravate the symptoms of peripheral arterial circulatory disorders, mainly due to its blood pressure lowering effect. - Where Betaloc is prescribed for a patient known to be suffering from a phaeochromocytoma, an α-blocker should be given concomitantly. - Prior to surgery the anaesthetist should be informed that the patient is receiving Betaloc. It is not recommended to stop β-blocker treatment in patients undergoing surgery. - Abrupt interruption of the medication is to be avoided. If treatment has to be withdrawn it should, when possible, be done gradually. Many patients can be withdrawn over a 14 day period. This can be done by cutting the daily dose in sequential steps, reaching a final dose of 25 mg once a day (half a 50 mg tablet). During this period especially patients with known ischemic heart disease should be kept under close surveillance. The risk for coronary events, including sudden death, may increase during withdrawal of β-blockade. - In patients taking β-blockers anaphylactic shock assumes a more severe form. - Pregnancy and lactation As with most drugs, Betaloc should not be given during pregnancy and lactation unless its use is considered essential. As with all antihypertensive agents, β-blockers may cause side-effects, e.g. bradycardia, in the fetus and in the newborn and breast-fed infant.

Product Type
human

Dosage
The tablets should be taken on an empty stomach. Hypertension: The recommended dosage in patients with hypertension is 100-200 mg daily, given as a single dose in the morning or in divided doses (morning and evening). If needed, the dose may be increased or other antihypertensive agents added. Long-term antihypertensive treatment with Betaloc in daily doses of 100-200 mg has been shown to reduce total mortality, including sudden cardiovascular death, stroke and coronary events in hypertensive patients. Angina pectoris: The recommended dosage is 100-200 mg daily, given in divided doses (morning and evening). If needed, other antianginal agents may be added. Cardiac arrhythmias: The recommended dosage is 100-200 mg daily given in divided doses (morning and evening). If needed, other antiarrhythmic agents may be added. Maintenance treatment after myocardial infarction: Long-term oral treatment with Betaloc in doses of 200 mg daily, given in divided doses (morning and evening) has been shown to reduce the risk of death (including sudden death), and to reduce the risk of reinfarction (also in patients with diabetes mellitus). Functional heart disorders with palpitations: The recommended dosage is 100 mg once daily, given as a single dose in the morning. If needed, the dose can be increased to 200 mg. Migraine prophylaxis: The recommended dosage is 100-200 mg daily, given in divided doses morning and evening. Hyperthyroidism: The recommended dosage is 150-200 mg daily, divided in 3-4 doses. If needed, the dose can be increased. Impaired renal function: Dose adjustment is not needed in patients with impaired renal function. Impaired hepatic function: Dose adjustment is normally not needed in patients suffering from liver cirrhosis because metoprolol has a low protein binding (5-10%). When there are signs of serious impairment of liver function (e.g. shunt-operated patients) a dose reduction should be considered. Elderly: Dose adjustment is not needed in the elderly. Children: There is limited experience with Betaloc treatment in children.

Adverse Reactions
Betaloc is well tolerated and adverse reactions have generally been mild and reversible. The following events have been reported as adverse events in clinical trials or reported from routine use. In many cases a relationship to treatment with Betaloc has not been established.
The following definitions of frequencies are used: Very common (>10%), common (1-9.9%), uncommon (0.1-0.9%), rare (0.01-0.09%) and very rare (<0 .01="" br="">- Cardiovascular system
Common: Bradycardia, postural disorders (very rarely with syncope), cold hands and feet, palpitations.
Uncommon: Transient deterioration of heart failure symptoms, cardiogenic shock in patients with acute myocardial infarction, AV-block I, oedema, pericordial pain.
Rare: Disturbances of cardiac conduction, cardiac arrhythmias.
Very rare: Gangrene in patients with pre-existing severe peripheral circulatory disorders.
- Central nervous system
Very common: Fatigue.
Common: Dizziness, headache.
Uncommon: Paraesthesiae, muscle cramps.
- Gastrointestinal
Common: Nausea, abdominal pain, diarrhoea, constipation.
Uncommon: Vomiting.
Rare: Dry mouth.
- Haematologic
Very rare: Thrombocytopenia.
- Hepatic
Rare: Liver function test abnormalities.
Very Rare: Hepatitis.
- Musculoskeletal
Very rare: Arthralgia.
- Metabolism
Uncommon: Weight gain.
- Psychiatric
Uncommon: Depression, concentration impaired, somnolence or insomnia, nightmares.
Rare: Nervousness, anxiety, impotence/sexual dysfunction.
Very rare: Amnesia/memory impairment, confusion, hallucinations.
- Respiratory
Common: Dyspnoea on exertion.
Uncommon: Bronchospasm.
Rare: Rhinitis.
- Sense organs
Rare: Disturbances of vision, dry and/or irritated eyes, conjunctivitis.
Very rare: Tinnitus, taste disturbances.
- Skin
Uncommon: Rash (in the form of urticaria psoriasiform and dystrophic skin lesions), increased sweating.
Rare: Loss of hair.
Very rare: Photosensitivity reactions, aggravated psoriasis. - Patients should know how they react to Betaloc before they drive or use machines because occasionally dizziness or fatigue may occur.

Contra Indications
- Atrioventricular block of second or third degree, patients with unstable decompensated cardiac heart failure (pulmonary oedema, hypoperfusion or hypotension), and patients with continuous or intermittent inotropic therapy acting through β-receptor agonism; marked clinically relevant sinus bradycardia, sick-sinus syndrome, cardiogenic shock, severe peripheral arterial circulatory disorder.
- Betaloc should not be given to patients with suspected acute myocardial infarction as long as the heart rate is less than 45 beats/min, the P-Q interval is more than 0.24 sec or the systolic blood pressure is less than 100 mm Hg.
- Betaloc tablets are contra-indicated in patients who have shown hypersensitivity to any component of the product or to other β-blockers.

Drug Interactions
- Metoprolol is a metabolic substrate for the Cytochrome P450 isoenzyme CYP2D6. Drugs that act as enzyme-inducing and enzyme-inhibiting substances may exert an influence on the plasma level of metoprolol. Plasma levels of metoprolol may be raised by co-administration of compounds metabolised by CYP2D6, e.g. antiarrhythmics, antihistamines, histamine-2-receptor antagonists, antidepressants, antipsychotics, and COX-2-inhibitors. The plasma concentration of metoprolol is lowered by rifampicin and may be raised by alcohol and hydralazine. - Patients receiving concomitant treatment with sympathetic ganglion blocking agents, other β-blockers (i.e. eye drops), or Mono Amine Oxidase (MAO) inhibitors should be kept under close surveillance. - If concomitant treatment with clonidine is to be discontinued, the β-blocker medication should be withdrawn several days before clonidine. - A watch should be kept for possible negative inotropic and chronotropic effects when metoprolol is given together with calcium antagonists of the verapamil and diltiazem type and/or antiarrhythmic agents. In patients treated with β-blockers intravenous administration of calcium antagonists of the verapamil-type should not be given. - β-blockers may enhance the negative inotropic and negative dromotropic effect of antiarrhythmic agents (of the quinidine type and amiodarone). - Digitalis glycosides, in association witβ-blockers, may increase atrioventricular conduction time and may induce bradycardia. - In patients receiving β-blocker therapy, inhalation anaesthetics enhance the cardiodepressant effect. - Concomitant treatment with indomethacin or other prostaglandin synthetase inhibiting drugs may decrease the antihypertensive effect of β-blockers. - Under certain conditions, when adrenaline is administered to patients treated with β-blockers, cardioselective β-blockers interfere much less with blood pressure control than non-selective β-blockers. - The dosages of oral antidiabetics may have to be readjusted in patients receiving β-blockers.

Search Post

Label :

Panadol Extra Film Coated Tablets

Panadol Extra Film Coated Tablets
Paracetamol 500 mg /tab.+ Caffeine 65 mg/tab.

Indications
Panadol Extra Tablets are indicated for the relief of pain and fever from: headache, migraine, common cold and flu, sore throat, earache, toothache, backache, rheumatic and muscular pain, neuralgia and period pain.

Company Name
Alexandria/Glaxosmith

Therapeutic Group
NON-NARCOTIC ANALGESICS

Pharmaceutical form
Tablets

Package
24 tablets

Indications
Panadol Extra Tablets are indicated for the relief of pain and fever from: headache, migraine, common cold and flu, sore throat, earache, toothache, backache, rheumatic and muscular pain, neuralgia and period pain.

Warning & Precautions
This preparation contains paracetamol. Do not take other paracetamol containing medications at the same time. Keep this and all medication out of the reach of children. Panadol Extra Tablets should be used with caution in cases of severe liver or kidney damage. Do not take this product for pain for more than 10 days or for fever for more than 3 days unless directed by a doctor. If pain or fever persists or gets worse, if new symptoms occur, or if redness and swelling is present, consult a doctor because these could be signs of a serious condition. If sore throat is severe and persists for more than 2 days, is accompanied by fever, headache, rash, nausea or vomiting, consult a doctor promptly.

Product Type
Human

Dosage
Panadol Extra Tablets are suitable for adults and children over 12 years of age.
Adults
Two tablets up to four times a day
Not recommended for children under 12 years
If necessary the dose may be repeated every four hours but do not take more than four doses in 24 hours.

Adverse Reactions
When taken in recommended doses, Panadol Extra is usually free from side effects. However skin reactions such as urticaria have been reported rarely.

Contra Indications
Panadol Extra Tablets are contra-indicated in patients with known hypersensitivity to paracetamol.

Drug Interactions
Panadol Extra Tablets may interact with anticoagulant agents on prothrombin time.
The liver effects of Panadol Extra Tablets may be increased by the use of alcohol and the concomitant use of certain drugs which enhance the metabolism of Panadol in the liver (i.e. barbiturates, tricyclic antidepressants).
The anticoagulant effect of warfarin and other coumarins may be enhance by prolonged daily use of paracetamol with increased risk of bleeding; occasional doses have no significant effect.

Search Post

Label :

Panadol 500 mg Film Coated Tablets | Paracetamol for the relief of pain and fever

Panadol 500 mg Film Coated Tablets
Paracetamol 500 mg /tab.

Company Name
Alexandria/Glaxosmith

Therapeutic Group
NON-NARCOTIC ANALGESICS

Pharmaceutical form
Tablets

Package
24 tablets

Indications
Panadol Tablets are indicated for the relief of pain and fever from: headache, migraine, common cold and flu, sore throat, earache, toothache, backache, rheumatic and muscular pain, neuralgia and period pain.

Warning & Precautions
This preparation contains paracetamol. Do not take other paracetamol containing medications at the same time. Keep this and all medication out of the reach of children. Panadol should be used with caution in cases of severe liver or kidney damage. Do not take this product for pain for more than 10 days or for fever for more than 3 days unless directed by a doctor. If pain or fever persists or gets worse, if new symptoms occur, or if redness and swelling is present, consult a doctor because these could be signs of a serious condition. If sore throat is severe and persists for more than 2 days, is accompanied by fever, headache, rash, nausea or vomiting, consult a doctor promptly.

Product Type
Human

Dosage
Panadol Tablets are suitable for adults and children over 6 years of age.
If necessary the dose may be repeated every four hours but do not take more than four doses in 24 hours.
Adults
Two tablets up to four times a day; not more than 8 tablets in 24 hours.
Children (6 to 12 years)
Half to one tablets up to four times a day; not more than 4 tablets in 24 hours
Not recommended for children under 6 years.

Adverse Reactions
When taken in recommended doses, Panadol is usually free from side effects. However skin reactions such as urticaria have been reported rare

Contra Indications
Panadol Tablets are contra-indicated in patients with known hypersensitivity to paracetamol.

Drug Interactions
Panadol Tablets may interact with anticoagulant agents on prothrombin time
The liver effects of Panadol Tablets may be increased by the use of alcohol and the concomitant use of certain drugs which enhance the metabolism of Panadol in the liver (i.e. barbiturates, tricyclic antidepressants).
The anticoagulant effect of warfarin and other coumarins may be enhance by prolonged daily use of paracetamol with increased risk of bleeding occasional doses have no significant effect.

Search Post

Label :

Thrombophob | Gel Heparin sodium

Thrombophob Gel
Heparin sodium 60000 I.U/100 gm

Company Name
Alexandria/Abbott

Therapeutic Group
TOP.ANTIVARICOSE PREPS

Pharmaceutical form
Gel

Package
Tube of 30 gm

Indications
For adjunctive treatment of: Superficial thrombosis and thrombophlebitis (Infusion), superficial varicose veins. Injuries due to sports and accidents: hematomas, bruises, contusion, dislocations, bursitis, and tendovaginitis. Leg ulcers ( ulcus cruris ) .

Warning & Precautions
Thrombophob 60000 gel should not be applied on open wounds, but on the surrounding skin only.

Product Type
Human

Dosage
Unless otherwise prescribed, Thrombophob 60000 gel is applied 2 – 3 times daily on the affected area.

Adverse Reactions
Isolated cases of allergic reactions have been reported (vasculitis due to hypersensitivity).

Contra Indications
Known hypersensitivity to heparin or heparin preparations.

Drug Interactions
/

Search Post

Label :

Supristol Suspension | Sulfamoxole + Trimethoprim

Supristol Suspension
Sulfamoxole 200 mg/5 ml + Trimethoprim 40 mg/ 5 ml

Company Name
Alexandria/Abbott

Therapeutic Group
TRIMETHOPRIM COMBS

Pharmaceutical form
Suspension

Package
bottles of 60 ml

Indications
Infections of the respiratory system (acute and chronic bronchitis, pneumonia, bronchopneumonia, bronchiectasis, pleuritis). ENT infection; (tonsillitis, sinusitis, pharyngitis, otitis media) Infections of the gastrointestinal tract (enteritis, enterocolitis; typhoid and paratyphoid fever and other Salmonella infections, bact. dysentery) Infections of the biliary tract ( cholecystitis, cholangitis ) Infections of the urogenital tract (acute and chronic pyelonephritis, pyelitis; nonspecific urethritis including postgonorrheal forms; prostatitis, epididymitis, adnexitis, gonorrhea). Infections due to sensitive pathogens at other sites ( meningitis , toxoplasmosis, sepsis , endocarditis , wound infections , pyodermia , furunculosis,abscess, osteomyelitis )

Warning & Precautions
There must be regular checks of the blood picture during long -term administration of SUPRISTOL in patient s with known folic acid deficiency or where the patient is receiving other treatment which could cause folic acid deficiency or damage the Haematopoietic centers. If there are any changes in the red blood count indicative of folic deficiency, folic acid treatment should be initiated. This will not impair the therapeutic effect of SUPRISTOL. Functional disorders of the thyroid should monitored. Procaine should not be given concurrently. Because of the sulfonamide component of the preparation the concomitant use or alternating application of hexamethyleneteramine containing preparations should be refrained from.

Product Type
Human

Dosage
Unless otherwise prescribed by the physician, SUPRISTOL should be administered according to the following recommendations: - Adults : Initial dose (once) 20 ml – 4 measuring spoons, Maintenance dose (every 12hours) 10 ml – 2 measuring spoons. - Children 6-12 years: Initial dose (once) 10 –15 ml = 2-3 measuring spoons, Maintenance dose (every 12hours) 5 – 10 ml = 1 – 2 measuring spoons. - Children 1 – 6 years: Initial dose (once) 5 – 10 ml = 1 – 2 measuring spoons, Maintenance dose (every 12hours) 2.5 – 5 ml = ½ – 1 measuring spoons. - Babies 2–12 months : Initial dose (once) 2.5 ml – 5 ml = ½ – 1 measuring spoon, Maintenance dose (every 12hours) 1.2 – 2.5 ml=0.25 – 0.5 measuring spoons. The weight –related dosage schedule for children is: initial dose: 24 mg of SUPRISTOL / kg body weight (20 mg of sulphamoxole / 4 mg of trimethoprim). Maintenance dose: 12 mg of SUPRISTOL / kg body weight every 12 hours. (Which equals 4 mg / kg / day of trimethoprim) Each pack of SUPRISTOL syrup contains a 5 ml measuring spoon with additional markings for 2.5 ml and 1.25 ml. It is recommended to take SUPRISTOL in the morning and evening after meals with some liquid. The duration of treatment depends on the kind and course of the disease as well as on the sensitivity of the pathogens. If necessary, the attending physician may increase the dosage where by the dosage principle should be maintained .Treatment with SUPRISTOL should be continued for two more days after all symptoms of the disease have subsided .

Adverse Reactions
SUPRISTOL is well tolerated at the recommended dosage. In individual cases, nausea, vomiting or sensation of dizziness may occur during the treatment with SUPRISTOL; occasionally a drug rash may appear with itching and wheals. Changes in the blood count are possible in rare instances, which are however, mostly of little consequence. After discontinuing the medication, these changes usually recede without any further measures. If vomiting persists and extensive changes in the skin occur, the attending physician should be consulted before the treatment is continued .

Contra Indications
SUPRISTOL must not be given to patients who are hypersensitive to sulfonamides or trimethoprim; Severe disorders of liver function, severe renal insufficiency and disorders of the Haematopoietic system .In impaired renal function (serum creatinine levels over 3 mg /100 ml). SUPRISTOL should only be used under strict medical supervision because of the possibility of sulfonamide retention. If there is any doubt, serum creatinine clearance and, if necessary, the blood level of sulfonamide should be determined, Here, the dosage of Supristol must be adjusted to suit the excretory capacity of kidneys in each particular patient. Pharmacological and toxicological studies have not revealed any evidence of embryotoxicity when the drug is used in the recommended therapeutic dose range. Nevertheless, as a matter of principle. SUPRESTOL should be taken by pregnant women or women who could become pregnant only after they have consulted the doctor. In pregnant women, the therapeutic value of the preparation must be carefully weighed against the possible risk of impairing development of the embryo. SUPRISTOL should not be taken during confinement or during the lactation period. SUPRISTOL should not be employed for premature and newborn babies and for children during the first two months of life.

Drug Interactions
/

Search Post

Label :

Reducdyn | Citiolone + L-Cysteine

Reducdyn

Reducdyn | Citiolone+L-Cysteine for Acute hepatitis, liver diseases, intoxications, side effects of irradiation, Allergic dermatoses, pruritis.

Citiolone 50mg/tab. + L-Cysteine 50mg/tab.

Company Name

Alexandria/Abbott

   

Therapeutic Group

HEPATIC PROCT LIPOTROPICS

   

Pharmaceutical form

Tablet

   

Package

50 tablets

Reducdyn Indications

Reducdyn is used for acute hepatitis, infections and toxic liver diseases, intoxications, side effects of irradiation, Allergic dermatoses, pruritis.

   

Reducdyn Warning & Precautions

Product Type

Human

   

Reducdyn Dosage

3 tablets 3 times daily, to be swallowed whole with some liquid during or immediately after meals.

   

Adverse Reactions

/   

Contra Indications

/

   

Drug Interactions

/

Search Post

Label :

Eudyna Gel / Eudyna Cream

Eudyna Gel 

Tretinoin 0.05 gm / 100 gm

Company Name
Alexandria/Abbott
 
Therapeutic Group
TOPICAL ANTI-ACNE PREPS
 
Pharmaceutical form
Gel
 
Package
tube of 20 gm
 

Eudyna Indications

Acne vulgaris (A comedonica, A. pustulosa, A. papulosa, A. indurata), Acne venenata (halogen acne, steroid acne, acne caused by medication or cosmetics); Elastoidosis cutanea nodularis (colloid milium ).
 

Eudyna Warning & Precautions

Eudyna should not come into contact with the eyes. Avoid repeated application of Eudyna to the skin at the corners of the mouth and in the angles of the nose. Patients with sunburn should first allow this to subside before beginning treatment with Eudyna _ Avoid exposing the areas treated with Eudyna to sunlight. This warning is particularly di¬rected at persons who are subject to long exposure to sunlight for professional reasons, as well as patients who have a tendency to develop skin damage caused by sunlight. Exposure to artificial ultraviolet light (. sun lamps., solarium) should be avoided during treatment with Eudyna
 
 
Product Type
Human
 

Eudyna Dosage

Unless otherwise prescribed by the physician, patients with normal or darker skins should apply a thin layer of Eudyne gel or cream to the affected areas of the skin once or twice daily (in the morning and / or evening) after thorough cleaning. Patients with more sensitive fair skin are recommended to apply Eudyna only once daily or every other day. In general, how often Eudyna should be applied depend on the sever¬ity of the acne and the skin's reaction and, therefore should be determined by the physi¬cian. Eudyna should continue to be applied until the acne has disappeared; this normally occurs after about 6 to 7 weeks treatment. In cases where the frequency of application was reduced due to side effects or therapy even discontinued, treatment can be resumed once the side effects have subsided. Following a course of treatment it may be recommendable for young persons, at an age susceptible to acne vulgaris, to continue applying Eudyna, although less frequently, as prophylactic treatment. In 20 - 25 Years old patients with acne vulgaris, treatment is gen¬erally no longer required once the acne has disappeared. In highly super infected forms of acne (acne pustulosa ) a short term of treatment with an antibiotic, such as oral tetracycline, may be considered. The skin should be cleaned daily with abundant water at body (temperature and a mild soap. To avoid re-infection or spreading the infection, the use of face cloths, sponges or similar items is to be avoided as long as there are infected pimples. The treatment of acne with Eudyna is enhanced by a diet low in fats and rich in vitamins; regulation of the digestion is also favorable
 
Adverse Reactions
When using Eudyna, redness, tightening, itchiness and/or burning sensation may be ex-perienced on the treated areas. Comedones may develop into small pimples at the beginning of treatment, i.e. there may be an apparent exacerbation of the signs of infection. The severity of the aggravation wiII depends on both the dose and frequency of Eudyna administration as well as the individual’s sensitivity to the treatment. In general, the irritation and pimples disappear in the fur¬ther course of treatment. The pigmentation of the skin may be diminished.
 
Contra Indications
Eudyna should not be used: On open wounds, in acute dermatitis, acute eczeme and rosacea.
 
Drug Interactions
/

---

Eudyna Cream

Tretinoin
Company Name
Alexandria/Abbott
 
Therapeutic Group
TOPICAL ANTI-ACNE PREPS
 
Pharmaceutical form
Cream
 
Eudyna Indications
Acne vulgaris (A comedonica, A. pustulosa, A. papulosa, A. indurata), Acne venenata (halogen acne, steroid acne, acne caused by medication or cosmetics); Elastoidosis cutanea nodularis (colloid milium ).
 
Eudyna Warning & Precautions
Eudyna should not come into contact with the eyes. Avoid repeated application of Eudyna to the skin at the corners of the mouth and in the angles of the nose. Patients with sunburn should first allow this to subside before beginning treatment with Eudyna Avoid exposing the areas treated with Eudyna to sunlight. This warning is particularly di¬rected at persons who are subject to long exposure to sunlight for professional reasons, as well as patients who have a tendency to develop skin damage caused by sunlight. Exposure to artificial ultraviolet light (. sun lamps., solarium) should be avoided during treatment with Eudyna

 
Product Type
Human
 
Eudyna Dosage
Unless otherwise prescribed by the physician, patients with normal or darker skins should apply a thin layer of Eudyne gel or cream to the affected areas of the skin once or twice daily (in the morning and / or evening) after thorough cleaning. Patients with more sensitive fair skin are recommended to apply Eudyna only once daily or every other day. In general, how often Eudyna should be applied depend on the sever¬ity of the acne and the skin's reaction and, therefore should be determined by the physi¬cian. Eudyna should continue to be applied until the acne has disappeared; this normally occurs after about 6 to 7 weeks treatment. In cases where the frequency of application was reduced due to side effects or therapy even discontinued, treatment can be resumed once the side effects have subsided. Following a course of treatment it may be recommendable for young persons, at an age susceptible to acne vulgaris, to continue applying Eudyna, although less frequently, as prophylactic treatment. In 20 - 25 Years old patients with acne vulgaris, treatment is gen¬erally no longer required once the acne has disappeared. In highly super infected forms of acne (acne pustulosa ) a short term of treatment with an antibiotic, such as oral tetracycline, may be considered. The skin should be cleaned daily with abundant water at body (temperature and a mild soap. To avoid re-infection or spreading the infection, the use of face cloths, sponges or similar items is to be avoided as long as there are infected pimples. The treatment of acne with Eudyna is enhanced by a diet low in fats and rich in vitamins; regulation of the digestion is also favorable.
 
Eudyna Adverse Reactions
When using Eudyna, redness, tightening, itchiness and/or burning sensation may be ex¬perienced on the treated areas. Comedones may develop into small pimples at the beginning of treatment, i.e. there may be an apparent exacerbation of the signs of infection. The severity of the aggravation wiII depends on both the dose and frequency of Eudyna administration as well as the individual’s sensitivity to the treatment. In general, the irritation and pimples disappear in the fur¬ther course of treatment. The pigmentation of the skin may be diminished.
 
Eudyna Contra Indications
Eudyna should not be used: On open wounds, in acute dermatitis, acute eczeme and rosacea.
 
Drug Interactions
/

Search Post

Label :

Ubretid ® | Distigmine bromide a treatment of post operative intestinal atony and meteorism

Ubretid ®

Distigmine bromide 5 mg / tab.

Company Name
ADCO/Nycomed - Austria

Pharmaceutical form
Tablets

Package
Box of 20 tablets in strips 5 mg / tablet.

Indications
- Prophylactic and therapeutic treatment of post operative intestinal atony and meteorism, particulary in operations with laparotomy, post operative paralytic ileus and infectious diseases, peritonitis, atonic constipation. - In atony and disturded evacuation of the urinary bladder and ureters after operation, spinal anaethesia, in treament with neuroleptics. - Neurogenic bladder of cerebral origin, in diseases of the spinal cord; pelvic trauma, Lesions of the pelvic nerve in surgical treatment of carcinoma of the cervix or the rectum. - Myasthenia gravis, incomplete after flaccid paralysis after poliomyelitis, diphtheria .... etc

Warning & Precautions
- Not to be given to newly born . - Pregnancy and lactation period. take Ubretid if specifically prescribed by your doctor. - This drug may import the mental alterness required for driving a car and operating machinery.

Product Type
Human

Dosage
Initially 5 mg (1 tablet) daily, is taken in the morning on empty stomach half an hour before breakfast, depending on the response increase to 2 tablest daily or decrease to one tablet every second or third day

Adverse Reactions
Intestinal spasms, sweating, salivation, nausea, vomiting and diarrhoea (muscarine - like effects). Fasciculation and muscular weakness , disturbed deglutition can occur with large doses (nicotine -like effects).

Contra Indications
- Recent myocardial infarction. - Severe hypotension, arterioventricular of impulse conduction, - Spastic states of the intestinal, biliary, urinary tracts and the bronchi. - Caution is necessary in hyperthyoidism

Drug Interactions
None

---

Ubretid ® Ampoule
Distigmine bromide 0.5 mg / ml




Company Name
ADCO/Nycomed - Austria

Pharmaceutical form
I.M.Ampoule

Package
Box of 25 ampoules each 0.5 mg / mlBox of 3 ampoules each 0.5 mg / mll. Box of 5 ampoules each 0.5 mg / mll.

Indications
- Prophylactic and therapeutic treatment of post operative intestinal atony and meteorism, particulary in operations with laparotomy, post operative paralytic ileus and infectious diseases, peritonitis, atonic constipation. - In atony and disturded evacuation of the urinary bladder and ureters after operation, spinal anaethesia, in treament with neuroleptics. - Neurogenic bladder of cerebral origin, in diseases of the spinal cord; pelvic trauma, Lesions of the pelvic nerve in surgical treatment of carcinoma of the cervix or the rectum. - Myasthenia gravis, incomplete after flaccid paralysis after poliomyelitis, diphtheria .... etc

Warning & Precautions
- Not to be given to newly born . - Pregnancy and lactation period. take Ubretid if specifically prescribed by your doctor. - This drug may import the mental alterness required for driving a car and operating machinery.

Product Type
Human

Dosage
Ampoules: 0.5 mg to not more than 1 mg I. M ., not to be repeated until after 24 hours have elapesd. Long term therapy can be given at 2 or 3 day intervals.

Adverse Reactions
Intestinal spasms, sweating, salivation, nausea, vomiting and diarrhoea (muscarine - like effects). Fasciculation and muscular weakness , disturbed deglutition can occur with large doses (nicotine -like effects).

Contra Indications
- Recent myocardial infarction. - Severe hypotension, arterioventricular of impulse conduction, - Spastic states of the intestinal, biliary, urinary tracts and the bronchi. - Caution is necessary in hyperthyoidism.

Drug Interactions
None

Search Post

Label :