Supristol Suspension
Sulfamoxole 200 mg/5 ml + Trimethoprim 40 mg/ 5 ml
Company Name
Alexandria/Abbott
Therapeutic Group
TRIMETHOPRIM COMBS
Pharmaceutical form
Suspension
Package
bottles of 60 ml
Indications
Infections of the respiratory system (acute and chronic bronchitis, pneumonia, bronchopneumonia, bronchiectasis, pleuritis). ENT infection; (tonsillitis, sinusitis, pharyngitis, otitis media) Infections of the gastrointestinal tract (enteritis, enterocolitis; typhoid and paratyphoid fever and other Salmonella infections, bact. dysentery) Infections of the biliary tract ( cholecystitis, cholangitis ) Infections of the urogenital tract (acute and chronic pyelonephritis, pyelitis; nonspecific urethritis including postgonorrheal forms; prostatitis, epididymitis, adnexitis, gonorrhea). Infections due to sensitive pathogens at other sites ( meningitis , toxoplasmosis, sepsis , endocarditis , wound infections , pyodermia , furunculosis,abscess, osteomyelitis )
Warning & Precautions
There must be regular checks of the blood picture during long -term administration of SUPRISTOL in patient s with known folic acid deficiency or where the patient is receiving other treatment which could cause folic acid deficiency or damage the Haematopoietic centers. If there are any changes in the red blood count indicative of folic deficiency, folic acid treatment should be initiated. This will not impair the therapeutic effect of SUPRISTOL. Functional disorders of the thyroid should monitored. Procaine should not be given concurrently. Because of the sulfonamide component of the preparation the concomitant use or alternating application of hexamethyleneteramine containing preparations should be refrained from.
Product Type
Human
Dosage
Unless otherwise prescribed by the physician, SUPRISTOL should be administered according to the following recommendations: - Adults : Initial dose (once) 20 ml – 4 measuring spoons, Maintenance dose (every 12hours) 10 ml – 2 measuring spoons. - Children 6-12 years: Initial dose (once) 10 –15 ml = 2-3 measuring spoons, Maintenance dose (every 12hours) 5 – 10 ml = 1 – 2 measuring spoons. - Children 1 – 6 years: Initial dose (once) 5 – 10 ml = 1 – 2 measuring spoons, Maintenance dose (every 12hours) 2.5 – 5 ml = ½ – 1 measuring spoons. - Babies 2–12 months : Initial dose (once) 2.5 ml – 5 ml = ½ – 1 measuring spoon, Maintenance dose (every 12hours) 1.2 – 2.5 ml=0.25 – 0.5 measuring spoons. The weight –related dosage schedule for children is: initial dose: 24 mg of SUPRISTOL / kg body weight (20 mg of sulphamoxole / 4 mg of trimethoprim). Maintenance dose: 12 mg of SUPRISTOL / kg body weight every 12 hours. (Which equals 4 mg / kg / day of trimethoprim) Each pack of SUPRISTOL syrup contains a 5 ml measuring spoon with additional markings for 2.5 ml and 1.25 ml. It is recommended to take SUPRISTOL in the morning and evening after meals with some liquid. The duration of treatment depends on the kind and course of the disease as well as on the sensitivity of the pathogens. If necessary, the attending physician may increase the dosage where by the dosage principle should be maintained .Treatment with SUPRISTOL should be continued for two more days after all symptoms of the disease have subsided .
Adverse Reactions
SUPRISTOL is well tolerated at the recommended dosage. In individual cases, nausea, vomiting or sensation of dizziness may occur during the treatment with SUPRISTOL; occasionally a drug rash may appear with itching and wheals. Changes in the blood count are possible in rare instances, which are however, mostly of little consequence. After discontinuing the medication, these changes usually recede without any further measures. If vomiting persists and extensive changes in the skin occur, the attending physician should be consulted before the treatment is continued .
Contra Indications
SUPRISTOL must not be given to patients who are hypersensitive to sulfonamides or trimethoprim; Severe disorders of liver function, severe renal insufficiency and disorders of the Haematopoietic system .In impaired renal function (serum creatinine levels over 3 mg /100 ml). SUPRISTOL should only be used under strict medical supervision because of the possibility of sulfonamide retention. If there is any doubt, serum creatinine clearance and, if necessary, the blood level of sulfonamide should be determined, Here, the dosage of Supristol must be adjusted to suit the excretory capacity of kidneys in each particular patient. Pharmacological and toxicological studies have not revealed any evidence of embryotoxicity when the drug is used in the recommended therapeutic dose range. Nevertheless, as a matter of principle. SUPRESTOL should be taken by pregnant women or women who could become pregnant only after they have consulted the doctor. In pregnant women, the therapeutic value of the preparation must be carefully weighed against the possible risk of impairing development of the embryo. SUPRISTOL should not be taken during confinement or during the lactation period. SUPRISTOL should not be employed for premature and newborn babies and for children during the first two months of life.
Drug Interactions
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