Dilozole susp | Diloxanide Furoate

Dilozole susp

Diloxanide Furoate 2gm% + Benzoyl Metronidazole 4gm%

Company Name

Alexandria

Therapeutic Group

ANAERUBICIDES

Pharmaceutical form

Suspension

Package

120 ml

Indications

Dilozole Suspension Diloxanide Furoate+ Benzoyl Metronidazole-for Acute amoebic dysentery. - Acute and chronic intestinal amoebiasis. - Extra-intestinal amoebiasis; hepatic and other systemic infections due to Entamoeba Histolytica. - Giardiasis .

Warning & Precautions

Patients should be advised to complete the course and not to drink alcoholic beverages while taking Dilozole. Clinical and laboratory monitoring is advised in patients receiving prolonged (.10 days) or intensive treatment with dilozole. Doses should be reduced in elderly and in patients with severe hepatic impairment. The drug should be avoided during pregnancy, especially during the first trimester. It should be avoided by nursing mothers or children less than 2 years of age.

Product Type

Human

Dosage
As directed by the physician or as follows: Adults: 2 tablets with meals 3 times daily for 5-10 days. Children 2-5 years: 1 teaspoonful (5 ml) 3 times daily for 5-10 days. Children 5-12 years: 2 teaspoonfuls (10 ml) 3 times daily for 5-10 days or 0.5-1 tablets

Adverse Reactions

Occasional mild gastrointestinal disturbances, flatulence, nausea, vomiting, metallic taste, headache, ataxia, urticaria, angioedema and darkening of urine may occur.

Contra Indications

Dilozole is contraindicated in case of hypersensitivity to the product.

Drug Interactions

When given with alcoholic beverage, Dilozole may produce disulfiram-like reaction with abdominal cramps; nausea, vomiting, headache, flushing and palpitations. Metronidazole impairs the metabolism or excretion of warfarin and other oral coumarin Anticoagulants, it increases blood levels of these agents, resulting in prolongation of prothrombin time. Co-administration with drugs increasing liver enzyme activity such as phenytoin or Phenobarbital may accelerate the elimination of metronidazole resulting in reduced plasma levels., with consequent reduction in the effectiveness of Dilozole. Simultaneous administration of drugs that decrease liver enzyme activity, such as cimetidine may prolong the half-life and decrease the plasma concentrations of metronidazole and might increase the risk of neurological side effects.

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