Naprosyn 250 mg tablets | Naproxen

Naprosyn 250 mg tablets

Naproxen 250 mg

Company Name
Misr/Gruninthal

Therapeutic Group
ANTIRHEUMATICS NON-S PLN

Pharmaceutical form
tablets

Package
NAPROSYN 250Tablets are supplied in packs of 20 tablets.

Naproxen Indications

NAPROSYN is indicated for the treatment of rheumatoid arthritis , osteoarthritis, ankylosing spondylitis , juvenile rheumatoid arthritis , acute gout and acute musculoskeletal disorders ( such as sprains and strains , direct trauma, lumbosacrsl pain , cervical spondylitis, , tenosynovitis and fibrositis)

Naproxen Warning & Precautions

NAPROSYN should be given under close supervision to patients with a history of gastro- intestinal disease. Bronchospasm may be precipitated in patients suffering from , or with history of bronchial asthma or allergic disease . Naprosyn decreases platelet aggregation & prolongs bleeding time .This effect should be kept in mind when bleeding times are determined. It is possible that patients with questionable or compromised cardiac function may be at a greater risk to develop sodium retention when taking NAPROSYN. Naprosyn should be used with great caution with impaired renal function & the monitoring of serum creatinine and/or creatinine clearance is advised in these patients. NAPROSYN is not recommended in patients having baseline creatinine clearance less than 30 ml/min. Certain patients , specifically those whose renal blood flow is compromised , should have renal function assessed before & during therapy . It is prudent to use the lowest effective dose in patients with impaired liver function . Medication is a product which affects your health , and its consumption contrary to instructions is dangerous for you. Follow strictly the doctor's prescription , the method of use and the instructions of the pharmacist who sales the medication . The doctor and the pharmacist are experts in medicine , it's benefits and risks Do not repeat the same prescription without consulting your doctor. Do not by yourself interrupt the period of treatment prescribed for you . Keep medication out of children .


Product Type
Human

Naproxen Dosage

Adults: Rheumatoid arthritis, osteoarthritis and ankylosing spondylitis : the usual dose is 500 mg to 1 gm daily taken in two doses at 1-2 hour intervals . where 1 gm per day is needed . The suggested regimen is one NAPROSYN 500 tablet twice daily. In acute gout, the recommended dosage is 750 mg at once, then 250 mg at 6-8 hours intervals as needed . with a maximum daily dose after the first day of 1250 mg. Children : NAPROSYN is effective in the treatment of juvenile rheumatoid arthritisin children over 5 years of age at a dose of 10 mg/kg/day taken in two doses at 12 hour intervals . NAPROSYN is not recommended for use in any other indication in children under 16 years of age.

Naproxen Adverse Reactions

Gastro-intestinal : The more frequent reactions are nausea, vomiting, abdominal discomfort & epigastric distress . More serious reactions , which may occur occasionally are gastrointestinal bleeding , peptic ulceration (sometimes with haemorrhage & perforation ) & colitis. Dermatological / hypersensitivity: Skin rashes , urticaria, angiodema. Anaphylactic reactions to naproxen & naproxen sodium formulations , eosinophilic ,pneumonitis , alopecia , erythema multiforme , Stevens johonson syndrome , epidermal necrolysis & photosensitivity reactions in which the skin resembles porphyria cutanea tarda pseudophorphyria or epidermolysis bullosa may occur rarely . CNS: Headache , insomnia, inability , inability to concentrate & cognitive dysfunction have been reported. Haematological: Thrombocytopenia , granulocytopenia , anaemia & haemolytic anaemia may occur rarely. Other: Tinnitus , hearing impairment , vertigo, mild peripheral edema, jaundice, fatal hepatitis, nephropathy , hematuria , visual disturbances , vasculitis , aseptic meningitis & ulcerative stomatitis have been reported rarely .

Naproxen Contra Indications

Active peptic ulceration Hypersensitivity to naproxen and naproxen sodium formulations,

Drug Interactions
Due to the high protein binding of NAPROSYN , patients simultaneously receiving hydantoins , anti-coagulants or a highly protein- bound sulphonamide should be observed for signs of overdosage of these drugs . No Interactions have been observed in clinical studies with NAPROSYN & anti-coagulants or sulphonylureas , but caution is nevertheless advised since interaction has been seen with other non- steroidal agents of this class. The natriuretic effect of frusemide has been reprted to be inhibited by some drugs of this class. Inhibition of renal lithium clearance leading to increase in lithium concentrations has been reported. NAPROSYN and other non-steroidal anti-inflammatory drugs can reduce the anti-hypertensive effect of propanol & other beta-blockers. Probenecid given concurrently increases NAPROSYN plasma levels & extends its half-life considerably. Caution is advised where methotrexate is administered concurrently because of possible enhancement of its toxicity since NAPROSYN , among other non-steroidal anti-inflammatory drugs , has been reported to reduce tubular secretion of methotrexate in an animal model. It is suggested that NAPROSYN therapy be temporarily discontinued 48 hours before adrenal function tests are performed . Because NAPROSYN may artifactually interfere with some tests for 17-ketogenic steroids , Similarly, NAPROSYN may interfere with some assays of urinary 5- hydroxy- indole acetic acid.

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