Antizole 200mg
Albendazole 200 mg/tab.
Company Name
Alexandria
Therapeutic Group
ANTHELMINTICS
Pharmaceutical form
Tablet
Package
2, 10, 20 or 100 tablets
Indications
Antizole (albendazole) is indicated for the treatment of the following infections: Neurocysticercosis. Antizole is indicated for the treatment of parenchymal neurocysticercosis due to active lesions caused by larval forms of the pork tapeworm, Taenia solium . Lesions considered responsive to albendazole therapy appear as nonenhancing cysts with no surrounding edema on contrast-enhanced computerized tomography Hydatid disease. Antizole is indicated for the treatment of cystic hydatid disease of the liver, lung, and peritoneum, caused by the larval form of the dog tapeworm, Echinococcus granulosus This indication is based on combined clinical studies which demonstrated non-infectious cyst contents in approximately 80-90% of patients given albendazole for 3 cycles of therapy of 28 days each
Warning & Precautions
General: Patients being treated for neurocysticercosis should receive appropriate steroid and anticonvulsant therapy as required. Oral or intravenous corticosteroids should be considered to prevent cerebral hypertensive episodes during the first week of anticysticeral therapy Pregnancy: Albendazole should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus Nursing Mothers: It is not known whether it is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when albendazole is administered to a nursing woman. Pediatric Use: Experience in children under the age of 6 years is limited. In hydatid disease, infection in infants and young children is uncommon, but no problems have been encountered in those who have been treated. In neurocysticercosis, infection is more frequently encountered
Product Type
Human
Dosage
As directed by the physician or as follows:
Dosing of Antizole will vary, depending upon which of the following parasitic infections is being treated.
Patients being treated for neurocysticercosis should receive appropriate steroid and anticonvulsant therapy as required.
Oral or intravenous corticosteroids should be considered to prevent cerebral hypertensive episodes during the first week of treatment.
Indication :
Hydatid Disease : Patient Weight (60 kg or greater) : Dose (400 mg b.i.d., with meals) : Duration (28-day cycle followed by a 14-day albendazole-free interval, for a total of 3 cycles).
Hydatid Disease : Patient Weight (less than 60 kg) : Dose (15 mg/kg/day given in divided doses b.i.d. with meals (maximum total daily dose 800 mg)) : Duration (28-day cycle followed by a 14-day albendazole-free interval, for a total of 3 cycles).
NOTE: When administering Antizole in the pre- or post-surgical setting, optimal killing of cyst contents is achieved when three courses of therapy have been given.
Neurocysticercosis : Patient Weight (60 kg or greater) : Dose (400 mg b.i.d., with meals) : Duration (8-30 days) .
Neurocysticercosis : Patient Weight (less than 60 kg) : Dose (15 mg/kg/day given in divided doses b.i.d. with meals (maximum total daily dose 800 mg)) : Duration (8-30 days).
Children up to 2 years of age:
10 mg /kg body weight as a single dose
Adverse Reactions
Abdominal pain, nausea/vomiting, headache, dizziness/vertigo Dermatologic: Rash, urticaria Hypersensitivity: Allergic reactions Acute renal failure has been observed Abnormal renal function test Leukopenia
Contra Indications
Antizole (albendazole) is contraindicated in patients with known hypersensitivity to the benzimidazole class of compounds
Drug Interactions
Dexamethasone: Steady-state trough concentrations of albendazole sulfoxide were about 56% higher when 8 mg dexamethasone was coadministered with each dose of albendazole (15 mg/kg/day) in eight neurocysticercosis patients. Cimetidine: Albendazole sulfoxide concentrations in bile and cystic fluid were increased (about 2-fold) in hydatid cyst patients treated with cimetidine (10 mg/kg/day) compared with albendazole (20 mg/kg/day) alone. Albendazole sulfoxide plasma concentrations were unchanged 4 hours after dosing.
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