Ampicillin 1gm vial
Ampicillin sodium eq. To 1gm ampicillin anhydrous
Company Name
Misr
Therapeutic Group
BROAD SPECT PENICILL INJ
Pharmaceutical form
vial
Package
A cartoon box contains a glass vial of 250mg or 500mg or 1000mg. ampicillin With insert.
Indications
urinary-tract infections, otitis media, sinusitis, oral infections, bronchitis, uncomplicated community-acquired pneumonia ,Haemophilus influenzae infections, invasive salmonellosis; listerial meningitis
Warning & Precautions
Patients known to be hypersensitive to penicillins should be given an antibacterial of another class Maculopapular rashes commonly occur with ampicillin but are not usually related to true penicillin allergy. erythematous rashes common in glandular fever, cytomegalovirus infection, and acute or chronic lymphocytic leukaemia. broad-spectrum penicillins should not therefore be used for ‘blind’ treatment of a sore throat. Care is necessary if very high doses of penicillins are given, especially if renal function is poor, because o the risk of neurotoxicity Renal, hepatic, and haematological status should be monitored during prolonged and high-dose therapy. Skin contact with penicillins should be avoided since sensitisation may occur Penicillin therapy changes the normal bacterial flora and can lead to supra-infection with penicillin-resistant organisms including Clostridium difficile or Candida, particularly with prolonged use.
Product Type
Human
Dosage
500 mg every 4–6 hours; child under 10 years, half adult dose *Endocarditis (in combination with another antibiotic if necessary), by intravenous infusion, 2 g every 6 hours, increased to 2 g every 4 hours e.g. in enterococcal endocarditis or if ampicillin used alone *Listerial meningitis (in combination with another antibiotic), by intravenous infusion, 2 g every 4 hours for 10–14 days; neonate 50 mg/kg every 6 hours; infant (1–3 months), 50–100 mg/kg every 6 hours; child( 3 months–12 years), 100 mg/kg every 6 hours (max. 12 g daily)
Adverse Reactions
hypersensitivity reactions including urticaria, fever, nausea, vomiting, joint pains, rashes, angioedema, anaphylaxis, serum sickness-like reaction; rarely CNS toxicity including convulsions (especially with high doses or in severe renal impairment), interstitial nephritis, haemolytic anaemia, leucopenia, thrombocytopenia, and coagulation disorders; also reported diarrhea (including antibiotic-associated colitis
Contra Indications
penicillin hypersensitivity or to any other ingrediants.
Drug Interactions
increased risk of rash when ampicillin given with allopurinol INR can be altered by a course of broad-spectrum penicillins such as ampicillin, although studies have failed to demonstrate an interaction with coumarins& phenindione penicillins reduce excretion of methotrexate (increased risk of toxicity) excretion of penicillins reduced by probenecid & sulfinpyrazone (increased plasma concentration) -antibacterials that do not induce liver enzymes possibly reduce contraceptive effect of oestrogens (risk probably small) antibacterials inactivate oral typhoid vaccin
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