Amoxycillin 500 mg

Amoxycillin 500 mg
Amoxycillin 500 mg/cap.

Company Name
Alexandria

Pharmaceutical form
Capsule

Package
12 or 36 Capsules

Indications
amoxycillin is indicated in the treatment of infections due to susceptible strains of the designated microorganisms in the conditions listed below: Infections of the ear, nose, and throat due to Streptococcus spp. ((alpha)- and (beta)-hemolytic strains only), Streptococcus pneumoniae, Staphylococcus spp., or H. influenzae Infections of the genitourinary tract due to E. coli, P. mirabilis , or E. faecalis Infections of the skin and skin structure due to Streptococcus spp. ((alpha)- and (beta)-hemolytic strains only), Staphylococcus spp., or E. coli. Infections of the lower respiratory tract due to Streptococcus spp. ((alpha)- and (beta)-hemolytic strains only), Streptococcus pneumoniae, Staphylococcus spp., or H. influenzae Gonorrhea, acute uncomplicated (ano-genital and urethral infections) due to N. gonorrhoeae (males and females) H. pylori eradication to reduce the risk of duodenal ulcer recurrence Triple therapy: Amoxycillin /clarithromycin/lansoprazole amoxycillin , in combination with clarithromycin plus lansoprazole as triple therapy, is indicated for the treatment of patients with H. pylori infection and duodenal ulcer disease (active or one-year history of a duodenal ulcer) to eradicate H. pylori . Eradication of H. pylori has been shown to reduce the risk of duodenal ulcer recurrence. Dual therapy: Amoxycillin /lansoprazole Amoxycillin , in combination with lansoprazole delayed-release capsules as dual therapy, is indicated for the treatment of patients with H. pylori infection and duodenal ulcer disease (active or one-year history of a duodenal ulcer) who are either allergic or intolerant to clarithromycin or in whom resistance to clarithromycin is known or suspected .

Warning & Precautions
Before initiating therapy with amoxycillin careful inquiry should be made concerning previous hypersensitivity reactions to penicillins, cephalosporins, or other allergens. If an allergic reaction occurs, amoxycillin should be discontinued and appropriate therapy instituted. Pseudomembranous colitis has been reported with nearly all antibacterial agents, including amoxycillin, and may range in severity from mild to life-threatening. Therefore, it is important to consider this diagnosis in patients who present with diarrhea subsequent to the administration of antibacterial agents. Treatment with antibacterial agents alters the normal flora of the colon and may permit overgrowth of clostridia. Studies indicate that a toxin produced by Clostridium difficile is a primary cause of “ antibiotic- associated colitis. “ After the diagnosis of pseudomembranous colitis has been established, appropriate therapeutic measures should be initiated. Mild cases of pseudomembranous colitis usually respond to drug discontinuation alone. In moderate to severe cases, consideration should be given to management with fluids and electrolytes, protein supplementation, and treatment with an antibacterial drug clinically effective against Clostridium difficile colitis.






















Product Type
Human

Dosage
As directed by the physician or as follows: Amoxycillin capsules may be given without regard to meals. For gonorrhea, treatment should be continued for a minimum of 48 to 72 hours beyond the time that the patient becomes a symptomatic or evidence of bacterial eradication has been obtained. It is recommended that there be at least 10 days, treatment for any infection caused by Streptococcus pyogenes to prevent the occurrence of acute rheumatic fever. Triple therapy: Amoxycillin/Clarithromycin/Lansoprazole The recommended adult dose is 1 g amoxycillin, 500 mg clarithromycin and 30 mg lansoprazole all given twice daily (every 12 hours) for 14 days. Dual therapy :Amoxycillin / Lansoprazole The recommended adult oral dose is 1 g amoxycillin and 30 mg lansoprazole, each given three times daily ( q 8 h ) for 14 days . Dosing recommendations for adults with impaired renal function: Patients with impaired renal function do not generally require a reduction in dose unless the impairment is severe. Severely impaired patients with glomerular filtration rate < 30 ml / minute should not receive the 750 mg amoxycillin. Patients with a glomerular filtration rate of 10 to 30 mL / minute should receive 500 mg or 250 mg every 12 hours, depending on the severity of the infection. Patients with a less than 10 mL/ minute glomerular filtration rate should receive 500 mg or 250 mg every 24 hours , depending on severity of the infection. Hemodialysis patients should receive 500 mg or 250 mg every 24 hours, depending on severity of the infection. They should receive an additional dose both during and at the end of dialysis. Adults patients: Adult patients: Infection Severity Usual adult dose Ear/ nose/ throat Mild/Moderate 500 mg every 12 hours or 250 mg every 8 hours Severe 750 mg every 12 hours or 500 mg every 8 hours Lower respiratory tract Mild/Moderate or severe 750 mg every 12 hours or 500 mg every 8 hours Skin/skin structure Mild/Moderate 500 mg every 12 hours or 250 mg every 8 hours Severe 750 mg every 12 hours or 500 mg every 8 hours Genitourinary tract Mild/Moderate 500 mg every 12 hours or 250 mg every 8 hours Severe 750 mg every 12 hours or 500 mg every 8 hours Gonorrhea Acute, uncomplicated ano-genital and urethral infections in males and females 3 grams as single oral dose Dosing for infections caused by less susceptible organisms should follow the recommendation for severe infections Children weighing 40 kg or more should be dosed according to the adult recommendations.

Adverse Reactions
Gastrointestinal :nausea, vomiting, diarrhea, and hemorrhagic/pseudomembranous colitis. Hypersensitivity Reactions: erythematous maculopapular rashes, erythema multiforme, Stevens-Johnson Syndrome, toxic epidermal necrolysis, and urticaria have been reported. Hemic and Lymphatic Systems: Anemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia . These reactions are usually reversible on discontinuation of therapy and are believed to be hypersensitivity phenomena.

Contra Indications
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Drug Interactions
Probenecid decreases the renal tubular secretion of amoxycillin. Concurrent use of amoxycillin and probenecid may result in increased and prolonged blood levels of amoxycillin. Chloramphenicol, macrolides, sulfonamides, and tetracyclines may interfere with the bactericidal effects of penicillin.

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