Cidolut depot 250 mg/Ampoule | hydroxy-progesterone- 17 caproate 250 mg

Cidolut depot 250 mg/Ampoule

Each ampoule one ml contains: 17-alpha-hydroxy-progesterone- 17 caproate 250 mg (in oily solution)
Company Name
CID

Therapeutic Group
PROGESTOG.EXCL G3A.G3F

Pharmaceutical form
Ampoule

Package
Box of : one ampoules each of 1 cc containing 250 mg .

Cidolut depot Indications

- Habitual abortion . - Primary and secondary amenorrhea . - Functional uterine bleeding ( Puberty and preclimacteric bleeding ) . - Polymenorrhoea .

Cidolut depot Warning & Precautions

- Cidolut depot should be used with caution in patients with cardiovascular diseases or renal impairment , diabetes mellitus , asthma , epilepsy , and migraine . - High doses of Cidolut depot should be used with caution in patients susceptible to thromboembolism . - Sometimes a local reaction may occur at the site of injection . - Rarely occurring : coughing , dyspnoea , and circulatory disturbance during or immediately after injection , but that can be avoided by injecting the drug very slowly .

Product Type
human

Cidolut depot Dosage

The high concentration contained in Cidolut depot takes into account the latest scientific discoveries about corpus luteum therapy. These have shown that it is often only possible to obtain a successful result using large doses . Over-dosage of progesterone and its derivatives is practically speaking not possible .The administration of Cidolut depot is always indicated if it is desired to obtain a corpus luteum effect extending over at least one week or longer. This is especially the case in the second half of the menstrual cycle and during pregnancy . I-Abortion : In cases of the tendency to habitual abortion , it is often advisable to administer larger doses of progesterone over a longer time than has either to been usual in order to preserve the pregnancy. In the tendency of habitual abortion . 125 to 250 mg of Cidolut depot should be injected at weekly intervals for at least the first half of pregnancy. II-Amenorrhea : Primary amenorrhea and secondary amenorrhea of relatively long duration: It is recommended that a cyclical treatment as described by Kaufmann be carried out over several months . Frequently a spontaneous cycle occurs subsequently . If this does not take place the treatment must be repeated over a few months. Using estradiol valerate and Cidolut depot it is found possible to carry out a cyclically correct treatment in a simple manner. At the beginning of treatment 10mg estradiol valerate are injected intramuscularly. Next either 10mg estradiol valerate are injected on the 14th day as well as 125 mg. Cidolut depot intramuscularly on the 14th and 22nd days or alternatively 10mg estradiol valerate together with 250mg Cidolut depot intramuscularly on the 18thday of treatment. Following the bleeding which resembles a menstruation and occurs approximately on the 28th day 10mg estradiol valerate intramuscularly are administered and on the 18th day of the artificial cycle 10mg estradiol valerate and 125mg Cidolut depot intramuscularly are given. III-Functional bleeding : (Cyclical glandular hyperplasia ) Especially puberty bleeding and pre-climacteric bleeding . Progesterone has a haemostatic action on the endometrium . the duration of the bleeding and the condition of endometrium are of great significance in the mechanism of this action . Estrogen should be injected simultaneously with : 125mg Cidolut depot - 10 mg Estradiol valerate . A few days later a menstruation like bleeding of limited duration may occur ( medical curettage) . When the bleeding is of long duration the desquamated endometrium should first of all be built up to the stage of proliferation by means of estrogen and then transformed by means of Cidolut depot . IV-Polymenorrhoea: In shortening of the phase of secretion, the time of ovulation may be easily determined by regular measurement of the morning temperature. 65 to 125mg of Cidolut depot should be injected intramuscularly between 20th and 22nd days.

Cidolut depot Adverse Reactions

17 alpha-hydroxy progesterone 17 caproate may cause gastro intestinal disturbances , fluid retention , edema , allergic skin rashes , breast changes including discomfort , changes in libido , hair loss , headache , premenstrual syndrome like symptoms and altered menstrual cycles or irregular menstrual bleeding .

Cidolut depot Contra Indications

- Undiagnosed vaginal bleeding . - Patients with a history or recurrent high risk of arterial disease . - Breast or genital carcinoma . - Hepatic impairment , especially if it is severe . - Diagnostically for pregnancy test . - Missed or incomplete abortion .

Cidolut depot Drug Interactions

- Enzyme inducing drugs such as carbamazepine , grisofulivin , phenobarbiton , phenytoin , and rifampicin may enhances the metabolism and clearance of progesterone . - Since hydroxyprogesterone caprote can influence the diabetic control, an adjustment in anti-diabetic dosage should be required . - Progesterone may inhibit cyclosporine concentration and increase a risk of toxicity .

Search Post

Label :