Pyrimethamine 25 mg
Company Name
Misr/Delta
Pharmaceutical form
tablets
Package
Box of 20 tab.
Indications
for malaria &toxoplasmosis
Warning & Precautions
*donot exceedthe dose *A small starting dose for toxoplasmosis to avoid nervous system toxicity *It is used with caution in patients with impared renal or hepatic function or in patientds with folate deficiency such as individulas with malabsorption syndrom, alcoholuism or pregnency and those receiving therapy such as phenytoin . *lab tests in patients receiving high dose semiweekly blood counts ,including platelets counts should be performed.
Product Type
Human
Dosage
For toxoplasmosis :Adult 50-75 mg with 1-7 gm daily of sulfonamide for 1-3 weeks Children :1 mg/kg/day in 2equal doses For malaria : : Adult :50 mg for 2 days Children : 4-10 years : 25 mg for 2 days For chemoprophylaxis of malaria :Adults &children over 10 years :25 mg(1tab ) once weekly Children 4-10 years :12.5 mg (1/2 tab ) once weekly Infants &children under 4 years : 6.25 mg (1/4tab ) once weekly
Adverse Reactions
Hypersensitivity anorexia & vomiting hematolodic effects megablastic anemia
Contra Indications
Hypersensitivity to pyrimethamine patients with megaloblastic anemia
Drug Interactions
pyrimethamine may be used with sulfonamides ,quinine &other antimalarials &with other antibiotics .however , concomitant use of other antifolic drugs or agents associated with myelosuppression as sulfonamides or trimethoprim-sulfamethazole ,proguanil,zidovudine,cytotoxic agents as methotrexate ,while patient receving pyrimethamine may inc bone marrow suppression risk. mild hepatotoxicity when use lorazepam with pyrimethamine
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