Baclofen. 25 mg B.P98
Baclofen25 mg
Company Name
Misr/Delta
Pharmaceutical form
tablets
Package
Box of 10&20 tab
Indications
Spasticity of the skeletal muscles in multiple sclerosis. * Spastic conditions occurring in spinal cord diseases of infectious, degenerative, traumatic, neoplastic or unknown origin as in spastic spinal paralysis, amyotrophic lateral sclerosis, syringomyelia, transverse myelitis, traumatic paraplegia or paraparesis and compression of the spinal cord.
Warning & Precautions
Uses in pregnancy only if benefit clearly justifies the potential risk to the fetus. * Not used for lactating mother because it excreated in the breast milk. Abrupt discontinuation of treatment should be avoided. *It has no significant benefit for patients with stroke. *It is not indicated in the treatment of skeletal muscle spasm resulting from rheumatic disorders, parkinsonism, cerebral palsy or trauma induced cerebral lesions.
Product Type
Human
Dosage
Adults: *Dosage is started with 5 mg daily 3 times daily then raised at 3-day intervals by 5mg increments every dose until the desired response is achieved . Optimum dosage is 30 mg to 75 mg daily. *In hospitalised patients daily dosages of 80-100 mg may be necessary. *In patients with impaired renal function or undergoing chronic haemodialysis, a particulary low dosage of about 5mg daily should be selected. *In elderly patients or in patients with spastic states of cerebral origin, the patient should be kept under appropriate surveillance. Children *Children aged 6-10 years : 30-60 mg/daily * In children over 10 years of age, a maximum dosage of 2.5 mg/kg body wt. may be given *Treatment is started with 2.5 mg 4 times daily, then raised cautiously at 3 days intervals until it becomes sufficient for individual child requirement . Paediatrics Dosage range is 0.75-2 mg/kg body weight
Adverse Reactions
With low doses , as recommended for the relief of painful muscle spasms ,side effects are rare and usually mild and transient , including : Constipation , nausea , urinary frequency , headache , insomnia, tinnitus, hypotension , drawsiness, dizziness, sedation, fatigue , weakness, rash, pruritus and ankle edema , muscle pain ,tremors ,epileptic seizures , slurred speech , palpitations , chest pain , dry mouth and respiratory depression may occur. In laboratory tests : increase liver enzyme level, increase level of alkaline phosphatase and increase of blood sugar.
Contra Indications
Should not be given to individuals with a history of Baclofensensitivity. Patients suffering from psychotic disorders, schizophrenia or confusional states should be treated cautiously with baclofen. Also used with caution in patients with a history of peptic ulcers, those suffering from cerebrovascular diseases or from respiratory, hepatic renal failure or prophyria. *Caution is excercised in patients with pre-existing hypertonic sphincter, epilepsy, automobiles or other dangerous machinery.
Drug Interactions
Sedation may occur if taken with CNS depressants or with alcohol. *During current treatment with tricyclic antidepressants, the effect of Baclofenmay be potentiated resulting in muscular hypotonia. * Concomitant treatment of Baclofenwith antihypertensives are likely to increase the fall in blood pressure. Also reports of mental confusion, hallucinations and agitation may occur in patients with Parkinson's disease receiving levodopa plus carbidopa
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