Clindamycin | Clindacin

Clindacin 150mg,300mg

Clindamycin hydrochloride hydrate 169.225 mg & 338.45 mg (Equivalent to Clindamycin base 150 mg & 300 mg)

Company Name

ADCO

Therapeutic Group

MACROLIDES & SIMILAR TYPE

Pharmaceutical form

Capsules

Package

16 capsules in two strips.

Indications

treatment of severe infections caused by susceptible Gram-positive aerobic organisms or by susceptible anaerobic organisms.

Warning & Precautions

"associated diarrhoea or colitis, which may progress to pseudomembraneous colitis, peritonitis, shock, toxic megacolon and death. Caution for individuals with a history of gastro-intestinal disease, especially colitis. If diarrhoea or colitis occurs clindamycin should be discontinued Periodic laboratory tests for renal and hepatic function should be carried out if treatment exceeds 10 days Close monitoring is also recommended in patients with renal or hepatic insufficiency, and in neonates and infants. Care should be observed inatopic individuals , not given with acute viral infection of the respiratory tract not be used in the treatment of meningitis. affect the reliability of contraceptives. Avoid in porphyria."

Product Type

Human

Dosage

"Adults:

The usual dose is 150 - 450 mg every six hours, depending on the severity of the infection.

Elderly patients:

Dosage requirements in elderly patients should not be influenced by age alone.

Children:

The usual dose is 3 - 6 mg/kg every six hours depending on the severity of the infection (not to exceed the adult dose)."

Adverse Reactions

Anaphylaxis Oesophageal ulcers, oesophagitis, nausea, vomiting abdominal pain and diarrhoea may progress to colitis including pseudomembraneous colitis.


Transient neutropenia (leucopenia), eosinophilla, agranulocytosis and thrombocytopenia, Maculopapular rash and urticaria, Jaundice and abnormalities in liver function, Renal dysfunction, Polyarthritis , Dysgeusia

Contra Indications

"Clindamycin is contra-indicated in patients with a history of hypersensitivity to clindamycin or lincomycin, or to any of the inactive ingredients in the capsules.

Clindamycin should not be used in patients with existing diarrhoea."

Drug Interactions

"Muscle relaxants:

Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. It should be used with caution, therefore, in patients receiving such agents.

Antibacterial agents:

clindamycin should not be given in combination with macrolides or streptogramin antibacterial agents.

Neostigmine and pyridostigmine

Clindamycin antagonises the effects of the above anticholinesterases.

Oestrogens:

Clindamycin possibly reduces the contraceptive effect of oestrogen. Though the risk is small, additional contraceptive precautions are recommended during concomitant use and for 7 days after discontinuing clindamycin.

Vaccines:

Oral typhoid vaccine is inactivated by concomitant administration of antibacterials. Thus, clindamycin should be avoided for 3 days before and after oral typhoid vaccination"

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